Structure
(Hoechst 33342 analog trihydrochloride, CAS 159277-19-7)
Patamostat mesylate Biochemical
Patamostat mesylate
Purity
98%
Synonyms
Patamostat mesylate; N/A; Patamostat mesylate biochemical
Purity/Purification
98%
CAS
114568-32-0
Targets&IC50
Thrombin:1.9 uM (IC50), plasmin:950 nM (IC50), Trypsin:39 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Patamostat mesylate (intravenous infusion) at 0.03-0.3mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1]. Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1]. Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2]. Animal Model: Male Wistar rats weighing about 350 g[2]. Dosage: 2 mg/kg. Administration: Continuous infusion per h for 1 h. Result: Significantly improved the survival rate.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Hoechst 33342 analog trihydrochloride, CAS 159277-19-7)
Structure
(Hoechst 33342 analog trihydrochloride, CAS 159277-19-7)
Structure
(Hoechst 33342 analog trihydrochloride, CAS 159277-19-7)
Structure
(Hoechst 33342 analog trihydrochloride, CAS 159277-19-7)
Related Product Information for Patamostat mesylate biochemical
Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC 50 s of 39 nM, 950 nM and 1.9 uM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.
References
1. Chazotte B. Labeling nuclear DNA with hoechst 33342. Cold Spring Harb Protoc. 2011 Jan 1;2011(1):pdb.prot5557.
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Product Notes
The Patamostat mesylate (Catalog #AAA227471) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Patamostat mesylate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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