Structure
Phorbol 12-myristate 13-acetate (PMA) Biochemical
Phorbol 12-myristate 13-acetate
Applications
Functional Assay
Purity
>98%
Synonyms
Phorbol 12-myristate 13-acetate (PMA); N/A; Phorbol 12-myristate 13-acetate; PMA; TPA; Phorbol ester; croton oil.; 12-O-Tetradecanoylphorbol-13-acetate; Phorbol 12-myristate 13-acetate (PMA) biochemical
Purity/Purification
>98%
Form/Format
Crystalline solid
Applicable Applications for Phorbol 12-myristate 13-acetate (PMA) biochemical
FA (Functional Assay)
Molecular Formula
C36H56O8
CAS Number
16561-29-8
Preparation and Storage
Store at -20 degree C.
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 100mM.
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 100mM.
Structure
Structure
Related Product Information for Phorbol 12-myristate 13-acetate (PMA) biochemical
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
References
Emerit, I., & Cerutti, P. A. (1981). Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action.
Holtmann, H. E. L. M. U. T., & Wallach, D. A. V. I. D. (1987). Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. The Journal of Immunology, 139(4), 1161-1167.
Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G.,... & June, C. H. (1989). CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proceedings of the National Academy of Sciences, 86(4), 1333-1337.
Holtmann, H. E. L. M. U. T., & Wallach, D. A. V. I. D. (1987). Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. The Journal of Immunology, 139(4), 1161-1167.
Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G.,... & June, C. H. (1989). CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proceedings of the National Academy of Sciences, 86(4), 1333-1337.
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Product Notes
The Phorbol 12-myristate 13-acetate (PMA) (Catalog #AAA79336) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Phorbol 12-myristate 13-acetate (PMA) can be used in a range of immunoassay formats including, but not limited to, FA (Functional Assay). Researchers should empirically determine the suitability of the Phorbol 12-myristate 13-acetate (PMA) for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phorbol 12-myristate 13-acetate (PMA), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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