Structure
(Z-Ala-Ala-Asn-AMC, CAS 149697-16-5)
Phosphoramide mustard Biochemical
Phosphoramide mustard
Purity
98%
Synonyms
Phosphoramide mustard; N/A; Cbz-Ala-Ala-Asn-AMC; Phosphoramide mustard biochemical
Purity/Purification
98%
CAS
10159-53-2
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Phosphoramide mustard (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats[2]. Phosphoramide mustard exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg)[2]. Animal Model: Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor[2]. Dosage: 2.1 mg/kg, 4.8mg/kg, 10.4 mg/kg, 20.7 mg/kg. Administration: intraperitoneal injection, once daily, for 5 consecutive days. Result: Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg. Animal Model: Rats[2]. Dosage: 59.4 mg/kg (Pharmacokinetic Analysis). Administration: Intravenous injection. Result: T 1/2 (15.1 min).
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Z-Ala-Ala-Asn-AMC, CAS 149697-16-5)
Structure
(Z-Ala-Ala-Asn-AMC, CAS 149697-16-5)
Structure
(Z-Ala-Ala-Asn-AMC, CAS 149697-16-5)
Structure
(Z-Ala-Ala-Asn-AMC, CAS 149697-16-5)
Related Product Information for Phosphoramide mustard biochemical
Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
References
1. Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510.
2. James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
3. Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035.
2. James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
3. Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035.
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Product Notes
The Phosphoramide mustard (Catalog #AAA227416) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Phosphoramide mustard, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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