Structure
(LyP-1, CAS 454487-07-1)
PROTAC CBP/P300 Degrader-1 Biochemical
PROTAC CBP/P300 Degrader-1
Purity
98%
Synonyms
PROTAC CBP/P300 Degrader-1; N/A; PROTAC CBP/P300 Degrader-1 biochemical
Purity/Purification
98%
CAS
2484739-48-0
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
PROTAC CBP/P300 Degrader-1 shows LNCaP prostate cancer cell viability inhibition (IC 50 =0.4 nM). PROTAC CBP/P300 Degrader-1 (10 nM) induces degradation of P300 (>= 80%)[1]. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancel cell lines (IC 50 s ranging from 0.1-141.4 nM for HEL, NOMO-1, MOLM-13, HL-60, MEG-01, MM.IS, MM.1R, NCL-H929, RPM-8226, AMO-1, WSU-DLCL2, Karpas-422, Pfeiffer, SU-DHL-1, LNCap clone FGC, VCap; 22RV1, NCI-H520, NCI-H703, LK-2, MCE-7, and SK-BR-3 cells)[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(LyP-1, CAS 454487-07-1)
Structure
(LyP-1, CAS 454487-07-1)
Structure
(LyP-1, CAS 454487-07-1)
Structure
(LyP-1, CAS 454487-07-1)
Related Product Information for PROTAC CBP/P300 Degrader-1 biochemical
PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines.
References
1. Fan Zhang, et al.Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide. Amino Acids. 2012 Jun;42(6):2343-51.
2. Ningning Song, et al. Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Deliv. 2019 Dec;26(1):363-375.
2. Ningning Song, et al. Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Deliv. 2019 Dec;26(1):363-375.
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Product Notes
The PROTAC CBP/P300 Degrader-1 (Catalog #AAA228470) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PROTAC CBP/P300 Degrader-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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