Structure
(Docetaxal, CAS 125354-16-7)
Protease-Activated Receptor-1, PAR-1 Agonist TFA Biochemical
Protease-Activated Receptor-1, PAR-1 Agonist TFA
Purity
98%
Synonyms
Protease-Activated Receptor-1, PAR-1 Agonist TFA; N/A; PNU-101383, 10-Acetyl docetaxel; Protease-Activated Receptor-1, PAR-1 Agonist TFA biochemical
Purity/Purification
98%
Solubility
H2O: 6.67 mg/mL (7.61 mM),
ultrasonic and warming and heat to 60 degree C
<1mg/ml refers to the product slightly soluble or insoluble
ultrasonic and warming and heat to 60 degree C
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Go 6976[2].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Docetaxal, CAS 125354-16-7)
Structure
(Docetaxal, CAS 125354-16-7)
Structure
(Docetaxal, CAS 125354-16-7)
Structure
(Docetaxal, CAS 125354-16-7)
Related Product Information for Protease-Activated Receptor-1, PAR-1 Agonist TFA biochemical
Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].
References
1. Gueritte-Voegelein, et al. Relationships between the structure of taxol analogs and their antimitotic activity. Journal of Medicinal Chemistry, 1991. 34(3), 992-998.
2. Yao, Peng, et al. Preparation of crystal form of dihydrate and DMSO solvate of anticancer compound CX1409. CN107793382A.
2. Yao, Peng, et al. Preparation of crystal form of dihydrate and DMSO solvate of anticancer compound CX1409. CN107793382A.
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Product Notes
The Protease-Activated Receptor-1, PAR-1 Agonist TFA (Catalog #AAA227129) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Protease-Activated Receptor-1, PAR-1 Agonist TFA, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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