Structure
(Mal-amido-PEG3-NHS ester, CAS 2055353-77-8)
PXS-4681A biochemical
PXS-4681A
Purity
98%
Synonyms
PXS-4681A; N/A; PXS-4681A biochemical
Purity/Purification
98%
CAS
1478364-87-2
Targets&IC50
SSAO:37 nM (Ki)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
PXS-4681A (2 mg/kg; PO; single dose) attenuates neutrophil migration, tumor necrosis factor-alpha, and interleukin-6 levels in mouse models of lung inflammation and localized inflammation[1]. In rats, PXS-4681A is well absorbed with good bioavailability and oral half-life at the 10 mg/kg i.v. dose and the 20 mg/kg PO dose. Similarly, in BALB/C mice, PXS-4681A is well absorbed with good bioavailability and oral half-life at 2 mg/kg in both intravenous and oral studies[1]. Animal Model: Carrageenan-induced skin inflammation mice[1]. Dosage: 2 mg/kg. Administration: oral administration; single dose. Result: Reduced local inflammation, causing a significant reduction in exudate volume by 25%.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Mal-amido-PEG3-NHS ester, CAS 2055353-77-8)
Structure
(Mal-amido-PEG3-NHS ester, CAS 2055353-77-8)
Structure
(Mal-amido-PEG3-NHS ester, CAS 2055353-77-8)
Structure
(Mal-amido-PEG3-NHS ester, CAS 2055353-77-8)
Related Product Information for PXS-4681A biochemical
PXS-4681A is a potent, selective, irreversible and orally active semicarbazide-sensitive amine oxidase (SSAO; VAP-1) inhibitor with a K i of 37 nM. PXS-4681A shows highly selectivity over related amine oxidases, ion channels, and seven-transmembrane domain receptors. PXS-4681A has anti-inflammatory effects.
References
1. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.
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Product Notes
The PXS-4681A (Catalog #AAA227746) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PXS-4681A, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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