Structure
(Posovolone, CAS 256955-84-7)
RGLS4326 biochemical
RGLS4326
Purity
98%
Synonyms
RGLS4326; N/A; Co 134444; RGLS4326 biochemical
Purity/Purification
98%
CAS
2229964-07-0
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
RGLS4326 preferentially distributes to kidney tubules and cysts. RGLS4326 (a single 3mg/kg SC injection) is rapidly absorbed into plasma, showing T max of <=1h, C max of 8.5ug/mL, and half-life of <4h in wild-type mice[1]. In vivo administration of RGLS4326 also upregulates the expression of the direct miR-17 target genes Pkd1 and Pkd2[1]. Animal Model: Pkd2 -KO mice[1]. Dosage: 20mg/kg. Administration: SC injection. Result: Compared to non-cystic control kidneys, polycystic kidneys of PBS-treated Pkd2 -KO mice exhibit an age-dependent progressive decline in miR-17 PD-Sig, indicative of increasing miR-17 activity with disease progression. Administration of RGLS4326 reversed this decline in miR-17 PD-Sig, indicating a sustained functional inhibition of miR-17.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Posovolone, CAS 256955-84-7)
Structure
(Posovolone, CAS 256955-84-7)
Structure
(Posovolone, CAS 256955-84-7)
Structure
(Posovolone, CAS 256955-84-7)
Related Product Information for RGLS4326 biochemical
RGLS4326 (RG4326) is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 inhibits miR-17 function in HeLa cells with an EC 50 value of 28.3 nM.
References
1. Vanover KE, et al. Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology (Berl). 2001;155(3):285-291.
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Product Notes
The RGLS4326 (Catalog #AAA228224) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RGLS4326, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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