Structure
(Zavacorilant, CAS 1781245-13-3)
RJW100 biochemical
RJW100
Purity
98%
Synonyms
RJW100; N/A; RJW100 biochemical
Purity/Purification
98%
CAS
1276664-20-0
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 uM[1]. RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 uM[1]. Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 uM) binding[1]. RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins[2]. RT-PCR[1]Cell Line: HEK293 cells Concentration: 1 uM, 5 uM, 10 uM Incubation Time: 24 hours. Result: Induced a significant dose-dependent increase in SHP transcripts beginning at 5 uM.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Zavacorilant, CAS 1781245-13-3)
Structure
(Zavacorilant, CAS 1781245-13-3)
Structure
(Zavacorilant, CAS 1781245-13-3)
Structure
(Zavacorilant, CAS 1781245-13-3)
Related Product Information for RJW100 biochemical
RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.6 and 7.5, respectively. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.
References
1. Hunt, et al.Octahydro fused azadecalin glucocorticoid receptor modulators.WO2015077530A1
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Product Notes
The RJW100 (Catalog #AAA227570) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RJW100, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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