Structure
(HA15-Biotin, CAS 1965310-52-4)
(S)-UFR2709 Biochemical
(S)-UFR2709
Purity
98%
Synonyms
(S)-UFR2709; N/A; (S)-UFR2709 biochemical
Purity/Purification
98%
CAS
1431628-22-6
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
(S)-UFR2709 (50-100 ug/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 ug/ml[2]. (S)-UFR2709 (50-100 ug/ml) decreases nicotine-evoked mRNA expression of alpha4 nACh receptor subunit, but UFR2709 has less effect on alpha4 nACh receptor subunit in the brain of adult zebrafish[2]. (S)-UFR2709 (intraperitoneal injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption. (S)-UFR2709 does not affect the weight or locomotor activity of the rats[1]. Animal Model: High-alcohol-drinking UChB rats[1]. Dosage: 10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg. Administration: intraperitoneal injection; 1-10 mg/kg; daily; 17 days. Result: Did not affect the weight or locomotor activity and reduced ethanol consumption and preference.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(HA15-Biotin, CAS 1965310-52-4)
Structure
(HA15-Biotin, CAS 1965310-52-4)
Structure
(HA15-Biotin, CAS 1965310-52-4)
Structure
(HA15-Biotin, CAS 1965310-52-4)
Related Product Information for (S)-UFR2709 biochemical
(S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for alpha 4 beta 2 nAChRs than for alpha 7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction.
References
1. Cerezo M, et, al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29(6):805-819.
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Product Notes
The (S)-UFR2709 (Catalog #AAA227706) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "(S)-UFR2709, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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