Structure
(9,10-Dichlorostearic acid, CAS 5829-48-1)
SHP2 protein degrader-1 Biochemical | SHP2 biochemical
SHP2 protein degrader-1
Purity
98%
Synonyms
SHP2 protein degrader-1; N/A; SHP2 biochemical
Purity/Purification
98%
CAS
2624181-69-5
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
SHP2 protein degrader-1 (compound SP4)(0-200 uM; 24 hours) inhibits the growth of Hela cells, with IC 50 of 5.77 and 4.30 nM, respectively, which are about 100 times higher than the activity of SHP099 (SHP2 inhibitor)[1]. SHP2 protein degrader-1 (compound SP4)(0-200 uM; 96 hours) induces 54.01% apoptotic death compared with 0.13% of the control at 100 nM[1]. SHP2 protein degrader-1 (compound SP4)(0-200 uM; 96 hours) induces cell cycle arrested at the G1 phase in Hela cells[1]. SHP2 protein degrader-1 (compound SP4)(0-200 uM; 96 hours) significantly inhibits the phosphorylation of JNK, Erk and p38[1]. SHP2 protein degrader-1 (compound SP4)(0-200 uM; 96 hours) inhibits RAS/MAPK signaling and cellular responses by a mechanism involving inhibition of SHP2 catalytic activity[1]. Cell Viability Assay[1] Cell Line: Hela cells Concentration: 0-200uM. Incubation Time: 24 hours. Result: Strongly inhibited the growth of Hela cells, with IC 50 of 5.77 and 4.30nM, respectively, which were about 100 times higher than the activity of SHP099 (SHP2 inhibitor). Apoptosis Analysis[1] Cell Line: Hela cells Concentration: 0-100uM Incubation Time: 96 hours. Result: Induced 54.01% apoptotic death compared with 0.13% of the control at 100 nM. While SHP099 at 1000 nM could induce 33.74% apoptotic death compared with 0.13% of the control. Cell Cycle Analysis[1] Cell Line: Hela cells Concentration: 0-100 uM. Incubation Time: 96 hours. Result: Induced cell cycle arrested at the G1 phase in Hela cells. Western Blot Analysis[1] Cell Line: Hela cells. Concentration: 0-100uM. Incubation Time: 96 hours. Result: Significantly inhibited the phosphorylation of JNK, Erk and p38.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(9,10-Dichlorostearic acid, CAS 5829-48-1)
Structure
(9,10-Dichlorostearic acid, CAS 5829-48-1)
Structure
(9,10-Dichlorostearic acid, CAS 5829-48-1)
Structure
(9,10-Dichlorostearic acid, CAS 5829-48-1)
Related Product Information for SHP2 biochemical
SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases.
References
1. G Ewald, et al. ATP leakage from ELD cells after exposure to stearic, monochlorostearic, dichlorostearic, and oleic acids. Pharmacol Toxicol
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Product Notes
The SHP2 (Catalog #AAA228539) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SHP2 protein degrader-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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