Structure
(3alpha-Hydroxy pravastatin sodium, CAS 81093-43-8)
Sinbaglustat Biochemical
Sinbaglustat
Purity
98%
Synonyms
Sinbaglustat; N/A; Sinbaglustat biochemical
Purity/Purification
98%
CAS
441061-33-2
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Sinbaglustat (OGT2378; administered p.o., in the powdered chow, at a dose of 2500 mg/kg/day, corresponding to 35-40 mg of Sinbaglustat per mouse per day) is highly effective in impeding melanoma tumor growth in vivo. The effectiveness of p.o. Sinbaglustat in this murine model suggests that inhibition of glycosphingolipid synthesis is a promising approach to inhibit tumor progression[1]. Animal Model: Female syngeneic C57BL/6 mice, 6-8 weeks old bearing MEB4 melanoma tumor[1]. Dosage: 35-40 mg per mouse per day. Administration: Administered p.o., in the powdered chow, at a dose of 2500 mg/kg/day. Result: Inhibited MEB4 melanoma tumor growth in a syngeneic, orthotopic murine model.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(3alpha-Hydroxy pravastatin sodium, CAS 81093-43-8)
Structure
(3alpha-Hydroxy pravastatin sodium, CAS 81093-43-8)
Structure
(3alpha-Hydroxy pravastatin sodium, CAS 81093-43-8)
Structure
(3alpha-Hydroxy pravastatin sodium, CAS 81093-43-8)
Related Product Information for Sinbaglustat biochemical
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions.
References
1. Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3alpha-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30(4):548?554.
2. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43(5):559?564.
2. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43(5):559?564.
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Product Notes
The Sinbaglustat (Catalog #AAA228716) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Sinbaglustat, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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