Structure
(Colominic acid sodium salt, CAS 70431-34-4)
SW157765 biochemical
SW157765
Purity
98%
Synonyms
SW157765; N/A; Polysialic acid sodium salt; SW157765 biochemical
Purity/Purification
98%
CAS
332063-87-3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Colominic acid sodium salt, CAS 70431-34-4)
Structure
(Colominic acid sodium salt, CAS 70431-34-4)
Structure
(Colominic acid sodium salt, CAS 70431-34-4)
Structure
(Colominic acid sodium salt, CAS 70431-34-4)
Related Product Information for SW157765 biochemical
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs.
References
1. Guy T. Barry, et al. COLOMINIC ACID, A POLYMER OF N-ACETYLNEURAMINIC ACID. J Exp Med. 1958 Apr 1;107(4):507-21.
2. Osama I Alwassil, et al. Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection. PLoS One. 2019 Oct 16;14(10):e0223413.
2. Osama I Alwassil, et al. Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection. PLoS One. 2019 Oct 16;14(10):e0223413.
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Product Notes
The SW157765 (Catalog #AAA228647) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SW157765, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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