Structure
(CPI-1328, CAS 2390367-27-6)
Thalidomide-NH-C6-NH-Boc Biochemical
Thalidomide-NH-C6-NH-Boc
Purity
98%
Synonyms
Thalidomide-NH-C6-NH-Boc; N/A; Thalidomide-NH-C6-NH-Boc biochemical
Purity/Purification
98%
CAS
2093536-13-9
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
MI-389 (0-1 uM; 72 hours) decreases cell growth with an EC 50 value of 21.3 nM, which is comparable to the cellular potency of sunitinib (EC 50 =17.3 nM)[1].MI-389 (0-500 nM; 72 hours) leads to GSPT1 destabilization fastly as a dosepdependent manner. It shows a complete GSPT1 depletion at 100 nM[1]. Cell Viability Assay[1]Cell Line: Kasumi-1 cells (a c-KIT dependent acute myeloid leukemia (AML) cell line); GIST-T1 Concentration: 0-1 uM Incubation Time: 72 hours. Result: Outperform decreased-antiproliferative effect than sunitinib Western Blot Analysis[1]Cell Line: Kasumi-1 cells (a c-KIT dependent acute myeloid leukemia (AML) cell line); GIST-T1 Concentration: 1 nM, 5 nM, 10 nM, 50 nM, 100 nM, 500 nM Incubation Time: 4 hours. Result: Decreased GSPT-1 protein expression.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(CPI-1328, CAS 2390367-27-6)
Structure
(CPI-1328, CAS 2390367-27-6)
Structure
(CPI-1328, CAS 2390367-27-6)
Structure
(CPI-1328, CAS 2390367-27-6)
Related Product Information for Thalidomide-NH-C6-NH-Boc biochemical
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
References
1. Stuckey JI, et al. Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity. J Biol Chem. 2021 Jan-Jun;296:100349.
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Product Notes
The Thalidomide-NH-C6-NH-Boc (Catalog #AAA228098) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Thalidomide-NH-C6-NH-Boc, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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