Structure
(GSK269962A hydrochloride, CAS 2095432-71-4)
Tiludronate disodiuM/hemihydrate Biochemical
Tiludronate disodiuM/hemihydrate
Purity
98%
Synonyms
Tiludronate disodiuM/hemihydrate; N/A; GSK 269962 hydrochloride; Tiludronate disodiuM/hemihydrate biochemical
Purity/Purification
98%
CAS
155453-10-4
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content[3].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(GSK269962A hydrochloride, CAS 2095432-71-4)
Structure
(GSK269962A hydrochloride, CAS 2095432-71-4)
Structure
(GSK269962A hydrochloride, CAS 2095432-71-4)
Structure
(GSK269962A hydrochloride, CAS 2095432-71-4)
Related Product Information for Tiludronate disodiuM/hemihydrate biochemical
Tiludronate (Tiludronic Acid) disodiuM/hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodiuM/hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodiuM/hemihydrate is a potent inhibitor of the osteoclast vacuolar H + -ATPase. Antiresorptive and anti-inflammatory properties[4].
References
1. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
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Product Notes
The Tiludronate disodiuM/hemihydrate (Catalog #AAA227793) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tiludronate disodiuM/hemihydrate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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