Structure
(DDR1-IN-4, CAS 2125676-13-1)
Uzansertib Biochemical
Uzansertib
Purity
98%
Synonyms
Uzansertib; N/A; Uzansertib biochemical
Purity/Purification
98%
CAS
1620012-39-6
Targets&IC50
Pim1:0.24 nM (IC50), Pim3:0.12 nM (IC50), Pim2:30 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Uzansertib (25-100 mg/kg; PO; twice a day; for 15 days) inhibits tumor growth in a dose-dependent manner in mice bearing MOLM-16 (AML) or KMS-12-BM (MM)[1]. Uzansertib demonstrates a dose-dependent inhibition of BAD phosphorylation relative to vehicle at 4 hours post dose (MOLM-16 tumors, IC 50 =70 nM; KMS-12-BM tumors, IC 50 =145 nM)[1]. Animal Model: Female immune compromised (severe combined immunodeficiency [SCID]) mice (5-9 weeks of age) bearing MOLM-16 (AML) or KMS-12-BM (MM)[1]. Dosage: 25, 50, 75, 100 mg/kg. Administration: PO; twice a day; for 15 days. Result: Inhibited tumor growth in a dose-dependent manner in mice.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(DDR1-IN-4, CAS 2125676-13-1)
Structure
(DDR1-IN-4, CAS 2125676-13-1)
Structure
(DDR1-IN-4, CAS 2125676-13-1)
Structure
(DDR1-IN-4, CAS 2125676-13-1)
Related Product Information for Uzansertib biochemical
Uzansertib (INCB053914) is an orally active, ATP-competitive pan- PIM kinase inhibitor with IC 50 s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines.
References
1. Hans Richter, et al. DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome. ACS Chem Biol. 2019 Jan 18;14(1):37-49.
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Product Notes
The Uzansertib (Catalog #AAA227826) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Uzansertib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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