XJB-5-131 biochemical

XJB-5-131

Cat. Num. AAA228926

• Purity: 98%
• Synonyms: XJB-5-131; N/A; Antiproliferative agent-14; XJB-5-131 biochemical

• Purity/Purification: 98%

• CAS: 866404-31-1
• Solubility: <1mg/ml refers to the product slightly soluble or insoluble
• In vitro: XJB-5-131 ameliorates peroxidation of the mitochondrial phospholipid, cardiolipin, in ileal mucosal samples from rats subjected to hemorrhagic shock (HS)[1]. Intravenous treatment with XJB-5-131 (2 umol/kg) significantly prolongs the survival of rats subjected to profound blood loss (33.5 mL/kg) despite administration of only a minimal volume of crystalloid solution (2.8 mL/kg) and the absence of blood transfusion[1]. XJB-5-131 reduces oxidative damage to mitochondrial DNA, maintains mitochondrial DNA copy number, suppresses motor decline and weight loss, enhances neuronal survival, and improves mitochondrial function. XJB-5-131 significantly suppresses the disease phenotypes and improves mitochondrial function in a mouse model of Huntington's disease (HD)[2]. XJB-5-131 (1 mg/kg; intraperitoneally injected; three times a week up to 57 weeks) suppresses decline of weight loss and motor function in a mouse model of HD[2]. Animal Model: Male specific pathogen-free Sprague-Dawley rats, weighing 150 to 250 g[1]. Dosage: 2 umol/kg. Administration: Administered intravenously using a syringe pump. Result: The rats treated with XJB-5-131 survived significantly longer (P< 0.01). Three of six survived for longer than 3 hours after completion of the hemorrhage protocol and one rat survived for the whole 6 hours postbleeding observation period. Animal Model: HD150KI mice[2]. Dosage: 1 mg/kg. Administration: Intraperitoneally injected; three times a week up to 57 weeks. Result: Chronic treatment suppressed weight loss. Increased the average body mass by 22%.
• Preparation and Storage: Powder: -20 degree C for 3 years; In solvent: -80 degree C for 2 years

Structure

(MT189, CAS 1885900-35-5)

Structure

(MT189, CAS 1885900-35-5)

Related Product Information for XJB-5-131 biochemical

XJB-5-131 is a mitochondria-targeted ROS and electron scavenger. XJB-5-131 is a bi-functional antioxidant that comprises a radical scavenger. XJB-5-131 is a synthetic antioxidant that targets mitochondria. XJB-5-131 is an effective ionizing irradiation protector and mitigator of cord blood mononuclear cells (CB MNCs).

Product Categories/Family for XJB-5-131 biochemical

Cytoskeletal Signaling

References

1. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372.