Application Data
CXCR3 blocking peptide
CXCR3 Blocking Peptide
Gene Names
CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
Applications
Western Blot, Immunohistochemistry
Synonyms
CXCR3; N/A; CXCR3 Blocking Peptide; C-X-C chemokine receptor type 3 antibody; CD 183 antibody; CD182 antibody; Chemokine CXC Motif Receptor 3 antibody; CKR L2 antibody; CKR-L2 antibody; CMKAR3 antibody; CXC-R3 antibody; G protein-coupled receptor 9 antibody; GPR9 antibody; Interferon-inducible protein 10 receptor antibody; IP-10 receptor antibody; Mig R antibody; Mig receptor antibody ; CXCR3 blocking peptide
Form/Format
Antigenic Blocking Peptide
Applicable Applications for CXCR3 blocking peptide
WB (Western Blot), IHC (Immunohistochemistry), Immunocompetition, Immunodepletion
Immunogen
Synthetic peptide taken within amino acid region 175-225 human CXCR3 protein
Molecular Function
G-Protein coupled receptor, Transducer, chemokine receptor activity
Subcellular Location
Cell membrane; Multipass membrane protein
Structure
Homomer, forms heteromers with ACKR4 by similarity
Preparation and Storage
Store at -20 degree C for long term storage
Application Data
Application Data
Related Product Information for CXCR3 blocking peptide
Synthetic peptide taken within amino acid region 175-225 on human CXCR3 protein.
Chemokines (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hematopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors articipate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases.
Activation of naive T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. The CXCR3 receptor protein is approximately 40-45 kDa protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The protein has putative N-glycosylation sites near the extracellular N-terminal end of the protein. The protein has a large 3rd intracellular loop which nteracts with G-proteins. The short carboxyl terminal is intracellular and has putative post-translational sites.
The Anti-CXCR3h-selective antibodies were generated against unique peptide sequence from the CXCR3 receptors gene that is expressed only in a CXCR3 receptor subtype of the human protein. The polyclonal antibodies were affinity purified on an immobilized antigen based affinity chromatography. Antigenic blocking peptides (MBS5401341) and western blot positive control (MBS542665) in ready to use SDS-sample buffers are available. Antibodies can be conjugated to fluorophores and other secondary enzymes upon request at nominal cost.
Chemokines (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hematopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors articipate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases.
Activation of naive T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. The CXCR3 receptor protein is approximately 40-45 kDa protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The protein has putative N-glycosylation sites near the extracellular N-terminal end of the protein. The protein has a large 3rd intracellular loop which nteracts with G-proteins. The short carboxyl terminal is intracellular and has putative post-translational sites.
The Anti-CXCR3h-selective antibodies were generated against unique peptide sequence from the CXCR3 receptors gene that is expressed only in a CXCR3 receptor subtype of the human protein. The polyclonal antibodies were affinity purified on an immobilized antigen based affinity chromatography. Antigenic blocking peptides (MBS5401341) and western blot positive control (MBS542665) in ready to use SDS-sample buffers are available. Antibodies can be conjugated to fluorophores and other secondary enzymes upon request at nominal cost.
Product Categories/Family for CXCR3 blocking peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
C-X-C chemokine receptor type 3 isoform 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 3
NCBI Official Symbol
CXCR3
NCBI Official Synonym Symbols
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
NCBI Protein Information
C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor
UniProt Protein Name
C-X-C chemokine receptor type 3
UniProt Gene Name
CXCR3
UniProt Synonym Gene Names
GPR9; CXC-R3; CXCR-3
UniProt Entry Name
CXCR3_HUMAN
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Product Notes
The CXCR3 cxcr3 (Catalog #AAA226416) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CXCR3 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), Immunocompetition, Immunodepletion. Researchers should empirically determine the suitability of the CXCR3 cxcr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCR3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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