CXCR7 blocking peptide
CXCR7 Peptide
Gene Names
ACKR3; RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
Applications
Immunocompetition, Immunodepletion
Synonyms
CXCR7; N/A; CXCR7 Peptide; ACKR3; atypical chemokine receptor 3; C X C chemokine receptor type 7; Chemokine orphan receptor 1; CMKOR1; CXC R7; G protein coupled receptor 159; G protein coupled receptor RDC1 homolog; GPR159; GPRN1; RDC 1 antibody; CXCR7 blocking peptide
Form/Format
Synthetic Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (varies by lot)
Sequence Length
362
Applicable Applications for CXCR7 blocking peptide
Immunocompetition, Immunodepletion
Immunogen
Synthetic peptide corresponding to unique amino acid sequence on human CXCR7 protein.
Expression
Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue.
Molecular Function
Cell adhesion, Host-virus interaction
Structure
Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasm degree perinuclear region. Early endosome. Recycling endosome
Preparation and Storage
-20 degree C for long term storage
Related Product Information for CXCR7 blocking peptide
Antigenic Blocking Peptide Chemokine (C-X-C motif) receptor 7 Antibody
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival.
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
41,493 Da
NCBI Official Full Name
Chemokine (C-X-C motif) receptor 7
NCBI Official Synonym Full Names
atypical chemokine receptor 3
NCBI Official Symbol
ACKR3
NCBI Official Synonym Symbols
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
NCBI Protein Information
atypical chemokine receptor 3
UniProt Protein Name
Atypical chemokine receptor 3
UniProt Gene Name
ACKR3
UniProt Synonym Gene Names
CMKOR1; CXCR7; GPR159; RDC1; CXC-R7; CXCR-7; RDC-1
UniProt Entry Name
ACKR3_HUMAN
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Product Notes
The CXCR7 ackr3 (Catalog #AAA75993) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CXCR7 can be used in a range of immunoassay formats including, but not limited to, Immunocompetition, Immunodepletion. Researchers should empirically determine the suitability of the CXCR7 ackr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCR7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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