Presenilin 1 Blocking Peptide | PSEN1 blocking peptide
Presenilin 1 Antibody Antigenic Blocking Peptide
Gene Names
PSEN1; AD3; FAD; PS1; PS-1; S182
Applications
Immunocompetition, Immunodepletion
Synonyms
Presenilin 1; N/A; Presenilin 1 Antibody Antigenic Blocking Peptide; AD3; FAD; Homo Sapiens Clone CC44 Senilin 1; Presenilin-1 CTF12; Protein S182; PS 1; PSEN1; S182 antibody; PSEN1 blocking peptide
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (varies by lot)
Sequence Length
376
Applicable Applications for PSEN1 blocking peptide
Immunocompetition, Immunodepletion
Immunogen
Synthetic Peptide
Expression
Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
Determinant
N-epitope
Molecular Function
Hydrolase, Protease
Structure
Homodimer
Subcellular Location
Endoplasmic Reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface
Preparation and Storage
-20 degree C for long term storage
Related Product Information for PSEN1 blocking peptide
Antigenic Blocking Peptide Presenilin 1 (Alzheimer disease 3) Antibody N-epitope
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
48,997 Da
NCBI Official Full Name
presenilin 1 (Alzheimer disease 3), isoform CRA_f
NCBI Official Synonym Full Names
presenilin 1
NCBI Official Symbol
PSEN1
NCBI Official Synonym Symbols
AD3; FAD; PS1; PS-1; S182
NCBI Protein Information
presenilin-1
UniProt Protein Name
Presenilin-1
UniProt Gene Name
PSEN1
UniProt Synonym Gene Names
AD3; PS1; PSNL1; PS-1; PS1-CTF12
UniProt Entry Name
PSN1_HUMAN
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Product Notes
The PSEN1 psen1 (Catalog #AAA76032) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Presenilin 1 can be used in a range of immunoassay formats including, but not limited to, Immunocompetition, Immunodepletion. Researchers should empirically determine the suitability of the PSEN1 psen1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Presenilin 1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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