CD38 recombinant protein
Human CD38 Recombinant
Purity
>95%, as determined by SDS-PAGE and HPLC
Synonyms
CD38; N/A; Human CD38 Recombinant; cd38; cd-38; CD38 recombinant protein
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Form/Format
Recombinant CD38 is supplied as a 0.2 um filtered PBS solution, pH7.2.
Sequence Length
300
Domain
ADP ribosyl cyclase
Host Note
Optimized DNA sequence encoding Human extracellular domain of human CD38 including a C-terminal 6His tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant CD38 is a monomer protein consisting of 269 amino acid residue subunits, due to glycosylation migrates as an approximately 45 kDa protein on SDS-PAGE.
Preparation and Storage
Recombinant CD38, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Related Product Information for CD38 recombinant protein
Human CD38 is a broadly expressed type II transmembrane glycoprotein of ~45 kDa in its monomeric form. This consists of a short intracytoplasmic (IC) tail, a transmembrane domain and a major extracellular domain (ECD) formed by 256 of the 300 constituent amino acids of the CD38 polypeptide.The CD38 ECD, where both receptor and enzymatic activities reside, harbours a 12 cysteine/6 disulfide signature common to the members of this family.
Product Categories/Family for CD38 recombinant protein
References
• the ac133+CD38–, but not the rhodamine-low, phenotype tracks ltc-ic and src function in human cord blood ex vivo expansion cultures .Blood, Jan 2010; 115: 257 - 260.
• CD38-mediated ca2+ signaling contributes to angiotensin ii-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation .J. Biol. Chem., Jan 2010; 285: 576 - 582.
• CD38 induces homing of chronic lymphocytic leukemia cells to the lymphoid organs through a functional interplay with cxcr4. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2328.
• CD38 expression on cd34+ cells as a single flow cytometric parameter to distinguish myelodysplastic syndromes (mds) from non-clonal cytopenias. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2783.
• CD38 cd49d are physically and functionally associated in b-cell chronic lymphocytic leukemia cells. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 357.
• CD38-mediated ca2+ signaling contributes to angiotensin ii-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation .J. Biol. Chem., Jan 2010; 285: 576 - 582.
• CD38 induces homing of chronic lymphocytic leukemia cells to the lymphoid organs through a functional interplay with cxcr4. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2328.
• CD38 expression on cd34+ cells as a single flow cytometric parameter to distinguish myelodysplastic syndromes (mds) from non-clonal cytopenias. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2783.
• CD38 cd49d are physically and functionally associated in b-cell chronic lymphocytic leukemia cells. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 357.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,328 Da
NCBI Official Full Name
ADP-ribosyl cyclase 1
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Gene Name
CD38
UniProt Synonym Gene Names
cADPr hydrolase 1
UniProt Entry Name
CD38_HUMAN
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Product Notes
The CD38 cd38 (Catalog #AAA76085) is a Recombinant Protein produced from HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders) and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CD38, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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