Application Data
(Immobilized Recombinant Human IGFBP7 / IBP-7 Protein (His Tag) ( Cat:13100-H08H) at 2ug/mL (100uL/well) can bind Recombinant Mouse CD93 Protein (Fc Tag) (#AAA259254), the EC50 is 150-450 ng/mL.)
C1qR1/CD93 recombinant protein
C1qR1/CD93 Protein, Mouse, Recombinant (hFc Tag), HPLC-verified
Gene Names
Cd93; Ly68; AA4.1; C1qr1; C1qrp; AA145088; AW555904; 6030404G09Rik
Purity
>= 95% as determined by SDS-PAGE.= 95% as determined by SEC-HPLC.
Synonyms
C1qR1/CD93; N/A; C1qR1/CD93 Protein, Mouse, Recombinant (hFc Tag), HPLC-verified; CD93 molecule; 6030404G09Rik Protein, Mouse; AA145088 Protein, Mouse; AA4.1 Protein, Mouse; AW555904 Protein, Mouse; C1qr1 Protein, Mouse; C1qrp Protein, Mouse; Ly68 Protein, Mouse; C1qR1/CD93 recombinant protein
Host
HEK293 Cells
Purity/Purification
>= 95% as determined by SDS-PAGE.
= 95% as determined by SEC-HPLC.
= 95% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Species
Mouse
Predicted N Terminal
Ala 23
Endotoxin
<1.0 EU per ug protein as determined by the LAL method.
Protein Construction
A DNA sequence encoding the Mouse CD93 (NP_034870.1)(Met1-Asn572) was expressed with the Fc region of human IgG1 at the C-terminus.
Activity
Immobilized Recombinant Human IGFBP7/IBP-7 Protein (His Tag)(Cat:13100-H08H) at 2ug/mL (100uL/well) can bind Recombinant Mouse CD93 Protein (Fc Tag) , the EC50 is 150-450 ng/mL.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Application Data
(Immobilized Recombinant Human IGFBP7 / IBP-7 Protein (His Tag) ( Cat:13100-H08H) at 2ug/mL (100uL/well) can bind Recombinant Mouse CD93 Protein (Fc Tag) (#AAA259254), the EC50 is 150-450 ng/mL.)
Application Data
(Immobilized Recombinant Human IGFBP7 / IBP-7 Protein (His Tag) ( Cat:13100-H08H) at 2ug/mL (100uL/well) can bind Recombinant Mouse CD93 Protein (Fc Tag) (#AAA259254), the EC50 is 150-450 ng/mL.)
Application Data
Application Data
Application Data
Application Data
Related Product Information for C1qR1/CD93 recombinant protein
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.
References
Bohlson SS, et al. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 175(2): 1239-47.
Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.
Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
69,354 Da
NCBI Official Full Name
complement component C1q receptor
NCBI Official Synonym Full Names
CD93 antigen
NCBI Official Symbol
Cd93
NCBI Official Synonym Symbols
Ly68; AA4.1; C1qr1; C1qrp; AA145088; AW555904; 6030404G09Rik
NCBI Protein Information
complement component C1q receptor
UniProt Protein Name
Complement component C1q receptor
UniProt Gene Name
Cd93
UniProt Synonym Gene Names
Aa4; C1qr1; C1qrp; Ly68; C1qR(p); C1qRp; Ly-68
UniProt Entry Name
C1QR1_MOUSE
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Product Notes
The C1qR1/CD93 cd93 (Catalog #AAA259254) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "C1qR1/CD93, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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