Application Data
Cadherin-11 Recombinant Protein | CDH11 recombinant protein
Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified
Gene Names
CDH11; OB; CAD11; CDHOB; OSF-4
Reactivity
Human
Purity
>= 90% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
Synonyms
Cadherin-11; N/A; Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified; Human Cadherin-11 Protein (His Tag); cadherin 11, type 2, OB-cadherin (osteoblast); CAD11 Protein, Human; CDHOB Protein, Human; ESWS Protein, Human; OB Protein, Human; OSF-4 Protein, Human; TBHS2 Protein, Human; CDH11 recombinant protein
Host
HEK293 Cells
Reactivity
Human
Purity/Purification
>= 90% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile 50mM Tris, 100mM NaCl, 3mM Cacl2, 10% Trehalose, 0.02% Tween20, pH 8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Sequence
Gly54-Thr617
Tag
C-His
Predicted N Terminal
Gly 54
Endotoxin
< 1.0 EU perug of the protein as determined by the LAL method
Protein Construction
A DNA sequence encoding the Human CDH11 (NP_001788)(Gly54-Thr617) was expressed with a polyhistidine tag at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Application Data
Application Data
Application Data
Application Data
Related Product Information for CDH11 recombinant protein
A mesenchymal marker, Cadherin-11's (CDH11) gene is situated on chromosome 16q22.1. CDH11 is a type II atypical cadherin, an integral membrane protein that mediates calcium-dependent, cell-cell homophilic interactions. Defined by a large extracellular N-domain, a single membrane-spanning domain, a small C-cytoplasmic domain, and the lack of an HAV cell adhesion recognition sequence, CDH11 expression is increased in fibrotic diseases such as systemic sclerosis, as well as in chronic inflammatory arthritis. CDH11 leads to promoter methylation inactivation, which can induce cancer cell apoptosis and suppress invasion through Wnt/beta-catenin, AKT/Rho A, and NF-kappaB signaling pathways. CDH11 mRNA and protein was expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that CDH11 may be a marker for aggressive, invasive tumor subsets.
Product Categories/Family for CDH11 recombinant protein
References
1.Che. X. e. al. Researc. progres. i. th. rol. an. mechanis. o. Cadherin-1. i. differen. diseases. . Cancer. 202. Ja. 1;12(4):1190-1199. doi. 10.7150/jca.52720. PMID. 33442417. 2.Sfikakis. Petro. P. e. al.Cadherin-1. a. . therapeuti. targe. i. chronic. inflammator. rheumati. diseases. Clinica. Immunology. 2017.doi:10.1016/j.clim.2017.01.00. 3.Thandiw. Chavula,Sara. To,Sandee. K. Agarwal. Cadherin-1. an. It. Rol. i. Tissu. Fibrosis.Cell. Tissue. Organs. 2023.https://doi.org/10.1159/00052535. 4.Satriy. PB. e. al. Cadheri. 1. Inhibitio. Downregulate. beta-catenin. Deactivate. th. Canonica. WN. Signallin. Pathwa. an. Suppresse. th. Cance. Ste. Cell-Lik. Phenotyp. o. Tripl. Negativ. Breas. Cancer. . Cli. Med. 201. Ja. 27;8(2):148. doi. 10.3390/jcm8020148. PMID. 30691241.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
76,457 Da
NCBI Official Full Name
cadherin-11 preproprotein
NCBI Official Synonym Full Names
cadherin 11, type 2, OB-cadherin (osteoblast)
NCBI Official Symbol
CDH11
NCBI Official Synonym Symbols
OB; CAD11; CDHOB; OSF-4
NCBI Protein Information
cadherin-11
UniProt Protein Name
Cadherin-11
UniProt Gene Name
CDH11
UniProt Synonym Gene Names
OB-cadherin
UniProt Entry Name
CAD11_HUMAN
Similar Products
Product Notes
The CDH11 cdh11 (Catalog #AAA259283) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Gly54-Thr6 17. It is sometimes possible for the material contained within the vial of "Cadherin-11, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.