CG 4305 Biochemical | CG4305 biochemical

CG 4305

Cat. Num. AAA227171

• Purity: 98%
• Synonyms: CG 4305; N/A; CG4305 biochemical

• Purity/Purification: 98%

• Solubility: DMSO: 10 mg/mL; ; DMF: 5 mg/mL; ; DMSO:PBS (pH 7.2)(1:10): 0.1 mg/mL; ; Ethanol: 3mg/mL; <1mg/ml refers to the product slightly soluble or insoluble
• Preparation and Storage: Powder: -20 degree C for 3 years; In solvent: -80 degree C for 2 years

Structure

(Sp-8-CPT-cAMPS, CAS 129693-13-6)

Structure

(Sp-8-CPT-cAMPS, CAS 129693-13-6)

Related Product Information for CG4305 biochemical

Prostacyclin (PGI2) is a cyclooxygenase metabolite with antithrombotic properties found in vascular endothelial cells. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. CG 4305 is a stable carbacyclic analog of PGI2 that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM. Doses of 10 mg/kg (oral) or 1 mg/kg (intraduodenal) have been shown to prevent rabbit carotid artery thrombosis.

References

1. Dostmann WR, et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91.
2. Boese M, et, al. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br J Pharmacol. 1996 Oct;119(4):707-15.
3. Spicuzza L, et, al. Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 2001 Aug;133(8):1201-12.