SDS-PAGE
((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)
Claudin-18.2(CLDN18.2)-Detergent Recombinant Protein | CLDN18.2 recombinant protein
Recombinant Human Claudin-18.2(CLDN18.2)-Detergent (Active)
Gene Names
CLDN18; SFTA5; SFTPJ; DKFZp564B2062
Purity
Greater than 80% as determined by SDS-PAGE.
Synonyms
Claudin-18.2(CLDN18.2)-Detergent; N/A; Recombinant Human Claudin-18.2(CLDN18.2)-Detergent (Active); (CLDN18.2); CLDN18.2 recombinant protein
Host
Mammalian cell
Purity/Purification
Greater than 80% as determined by SDS-PAGE.
Form/Format
Liquid. 50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Sequence
MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
Sequence Length
1-261aa; Full Length of Isoform A2
Species
Homo sapiens (Human)
Tag
C-terminal 10xHis-tagged
Transmembrane Domain
4TM
Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5ug/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody , the EC50 is 0.4640-0.6372ng/mL.
Preparation and Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
SDS-PAGE
((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)
SDS-PAGE
((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)
Bioactivity
Bioactivity
Related Product Information for CLDN18.2 recombinant protein
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Product Categories/Family for CLDN18.2 recombinant protein
References
"Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development."Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O.Clin. Cancer Res. 14:7624-7634(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,856 Da
NCBI Official Full Name
claudin-18 isoform 2
NCBI Official Synonym Full Names
claudin 18
NCBI Official Symbol
CLDN18
NCBI Official Synonym Symbols
SFTA5; SFTPJ; DKFZp564B2062
NCBI Protein Information
claudin-18; OTTHUMP00000216399; OTTHUMP00000216400; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J
UniProt Protein Name
Claudin-18
UniProt Gene Name
CLDN18
UniProt Entry Name
CLD18_HUMAN
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Product Notes
The CLDN18.2 cldn18 (Catalog #AAA279394) is a Recombinant Protein produced from Mammalian cell and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MAVTACQGLG FVVSLIGIAG IIAATCMDQW STQDLYNNPV TAVFNYQGLW RSCVRESSGF TECRGYFTLL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA LKCIRIGSME DSAKANMTLT SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS TANMYTGMGG MVQTVQTRYT FGAALFVGWV AGGLTLIGGV MMCIACRGLA PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI YDGGARTEDE VQSYPSKHDY V. It is sometimes possible for the material contained within the vial of "Claudin-18.2(CLDN18.2)-Detergent, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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