Claudin-9 (CLDN9) Recombinant Protein | CLDN9 recombinant protein

Recombinant Human Claudin-9 (CLDN9)-VLPs (Active)

Cat. Num. AAA279267

• Purity: The purity information is not available for VLPs proteins.
• Synonyms: Claudin-9 (CLDN9); N/A; Recombinant Human Claudin-9 (CLDN9)-VLPs (Active); Claudin-9; CLDN9 recombinant protein

• Host: Mammalian cell
• Purity/Purification: The purity information is not available for VLPs proteins.
• Form/Format: Lyophilized powder; Lyophilized from a 0.2 um filtered PBS, 6% Trehalose, pH 7.4
• Sequence Positions: 1-217aa; Full Length
• Sequence: MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV

• Species: Homo sapiens (Human)
• Tag: C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
• Research Area: CancerLess than 1.0 EU/ug as determined by LAL method.
• Transmembrane Domain: 4TM
• Biological_Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 10 ug/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 24.93-35.47 ng/mL.
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.; We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL. Aliquot for long-term storage at -80 degree C.Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.; The VLPs are expressed from human 293 cells (HEK293). Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended. Store the protein at -20 degree C/-80 degree C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.The immunization strategy should be optimized (antigen dose, regimen and adjuvant).

Bioactivity

(ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 10 ug/ml can bind Anti-CLDN6/9 recombinant antibody , the EC50 is 24.93-35.47 ng/mL.)

Application Data

(is detected by Mouse anti-6*His monoclonal antibody.)

Related Product Information for CLDN9 recombinant protein

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

Product Categories/Family for CLDN9 recombinant protein

MP-VLP Transmembrane Protein & Active Protein & In Stock Protein

References

"Claudin association with CD81 defines hepatitis C virus entry."Harris H.J., Davis C., Mullins J.G., Hu K., Goodall M., Farquhar M.J., Mee C.J., McCaffrey K., Young S., Drummer H., Balfe P., McKeating J.A.J. Biol. Chem. 285:21092-21102(2010)

NCBI and Uniprot Product Information

• NCBI GI #: 11141861
• NCBI GeneID: 9080
• NCBI Accession #: NP_066192.1
• NCBI GenBank Nucleotide #: NM_020982.3
• UniProt Accession #: O95484
• Molecular Weight: 22,848 Da
• NCBI Official Full Name: claudin-9
• NCBI Official Synonym Full Names: claudin 9
• NCBI Official Symbol: CLDN9
• NCBI Protein Information: claudin-9
• UniProt Protein Name: Claudin-9
• UniProt Gene Name: CLDN9
• UniProt Entry Name: CLD9_HUMAN