SDS-PAGE
(The purity was determined to be >75% by densitometry. Approx. MW 140kDa)
KAT3A (CREBBP) recombinant protein
KAT3A (CREBBP) recombinant protein
Gene Names
CREBBP; CBP; RSTS; KAT3A
Applications
Western Blot
Purity
>75%
Synonyms
KAT3A (CREBBP); N/A; KAT3A (CREBBP) recombinant protein; CREBBP; CBP; KAT3A; RSTS
Host
Sf9 insect cells
Purity/Purification
>75%
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.1ug/ul (varies by lot)
Sequence Positions
518-1207
Sequence Length
10197
Applicable Applications for KAT3A (CREBBP) recombinant protein
WB (Western Blot)
Type
Recombinant Fusion Protein
Species
Human
Tag Information
GST tag
Expression System
Sf9 insect cells using baculovirus
Source Note
Recombinant human KAT3A (518-1207) was expressed by baculovirus in Sf9 insect cells
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Stability: 1yr at -70 degree C from date of shipment.
Stability: 1yr at -70 degree C from date of shipment.
SDS-PAGE
(The purity was determined to be >75% by densitometry. Approx. MW 140kDa)
SDS-PAGE
(The purity was determined to be >75% by densitometry. Approx. MW 140kDa)
Related Product Information for KAT3A (CREBBP) recombinant protein
Recombinant human KAT3A (518-1207) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition (1). KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus (2).
Scientific Background: KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition (1). KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus (2).
Product Categories/Family for KAT3A (CREBBP) recombinant protein
References
1. Arias, J. et.al: Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370: 226-229, 1994.
2. Kasper, L. H. et.al: A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419: 738-743, 2002.
2. Kasper, L. H. et.al: A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419: 738-743, 2002.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~140 kDa
NCBI Official Full Name
Homo sapiens CREB binding protein (CREBBP), transcript variant 1, mRNA
NCBI Official Synonym Full Names
CREB binding protein
NCBI Official Symbol
CREBBP
NCBI Official Synonym Symbols
CBP; RSTS; KAT3A
NCBI Protein Information
CREB-binding protein
UniProt Protein Name
CREB-binding protein
UniProt Gene Name
CREBBP
UniProt Synonym Gene Names
CBP
UniProt Entry Name
CBP_HUMAN
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Product Notes
The KAT3A (CREBBP) crebbp (Catalog #AAA72897) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 518-1207 with tag GST tag!!Expression System||Sf9 insect cells using baculovirus!!Source Note||Recombinant human KAT3A (518-1207) was expressed by baculovirus in Sf9 insect cells. AAA Biotech's KAT3A (CREBBP) can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the KAT3A (CREBBP) crebbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KAT3A (CREBBP), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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