SDS-PAGE
Type II iodothyronine deiodinase Recombinant Protein | Dio2 recombinant protein
Recombinant Rat Type II iodothyronine deiodinase
Gene Names
Dio2; 5DII; DIOII
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Type II iodothyronine deiodinase; N/A; Recombinant Rat Type II iodothyronine deiodinase; 5DII DIOII Type 2 DI Type-II 5'-deiodinase; Dio2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-265aa (130:U-->MISS; 263:U-->S); Full-Length
Sequence
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECHLLDFASAERPLVVNFGSATPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRSILD
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for Dio2 recombinant protein
Catalyzes the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
References
Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues.Croteau W., Davey J.C., Galton V.A., St Germain D.L.J. Clin. Invest. 98:405-417(1996) Induction of type 2 deiodinase activity by cyclic guanosine 3',5'-monophosphate in cultured rat glial cells.Gondou A., Toyoda N., Nishikawa M., Tabata S., Yonemoto T., Ogawa Y., Tokoro T., Sakaguchi N., Wang F., Inada M.Thyroid 8:615-622(1998) Expression and nocturnal increase of type II iodothyronine deiodinase mRNA in rat pineal gland.Murakami M., Hosoi Y., Negishi T., Kamiya Y., Ogiwara T., Mizuma H., Yamada M., Iriuchijima T., Mori M.Neurosci. Lett. 227:65-67(1997) Night/day changes in pineal expression of >600 genes central role of adrenergic/cAMP signaling.Bailey M.J., Coon S.L., Carter D.A., Humphries A., Kim J.S., Shi Q., Gaildrat P., Morin F., Ganguly S., Hogenesch J.B., Weller J.L., Rath M.F., Moller M., Baler R., Sugden D., Rangel Z.G., Munson P.J., Klein D.C.J. Biol. Chem. 284:7606-7622(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
31.8 kDa
NCBI Official Full Name
type II iodothyronine deiodinase
NCBI Official Synonym Full Names
deiodinase, iodothyronine, type II
NCBI Official Symbol
Dio2
NCBI Official Synonym Symbols
5DII; DIOII
NCBI Protein Information
type II iodothyronine deiodinase
UniProt Protein Name
Type II iodothyronine deiodinase
UniProt Gene Name
Dio2
UniProt Synonym Gene Names
Itdi2; Txdi2
UniProt Entry Name
IOD2_RAT
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Product Notes
The Dio2 dio2 (Catalog #AAA115364) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-265aa (130:U-->MISS; 263:U-->S); Full-Length. The amino acid sequence is listed below: MGLLSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVALL LSRSKSTRGE WRRMLTSEGL RCVWNSFLLD AYKQVKLGED APNSSVVHVS NPEAGNNCAS EKTADGAECH LLDFASAERP LVVNFGSATP PFTRQLPAFR QLVEEFSSVA DFLLVYIDEA HPSDGWAVPG DSSMSFEVKK HRNQEDRCAA AHQLLERFSL PPQCQVVADR MDNNANVAYG VAFERVCIVQ RRKIAYLGGK GPFSYNLQEV RSWLEKNFSK RSILD. It is sometimes possible for the material contained within the vial of "Type II iodothyronine deiodinase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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