Application Data
Desmoglein-2 Recombinant Protein | DSG2 recombinant protein
Recombinant Human Desmoglein-2 Protein (His Tag), HPLC-verified
Gene Names
DSG2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB
Reactivity
Human
Purity
>= 95% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
Synonyms
Desmoglein-2; N/A; Recombinant Human Desmoglein-2 Protein (His Tag), HPLC-verified; Human Desmoglein-2 Protein (His Tag); desmoglein 2; CDHF5 Protein, Human; HDGC Protein, Human; DSG2 recombinant protein
Host
HEK293 Cells
Reactivity
Human
Purity/Purification
>= 95% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Sequence
Ala50-Gly609
Tag
C-His
Predicted N Terminal
Ala 50
Endotoxin
< 1.0 EU perug of the protein as determined by the LAL method
Protein Construction
A DNA sequence encoding the Human DSG2 (Q14126)(Ala50-Gly609) was expressed with a polyhistidine tag at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Application Data
Application Data
Application Data
Application Data
Related Product Information for DSG2 recombinant protein
Desmoglein-2 (Dsg2) is a specific cadherin of the cell-cell contact in cardiac desmosomes. Mutations in the DSG2-gene are regarded to cause arrhythmogenic (right ventricular) cardiomyopathy (ARVC) which is a rare but severe heart muscle disease. The depletion of DSG2 markedly decreased hPSC proliferation and pluripotency marker expression. In addition, DSG2-negative population in hPSCs exhibited a notable suppression in embryonic body and teratoma formation. The actions of DSG2 in regulating the self-renewal and pluripotency of hPSCs were predominantly exerted through the regulation of beta-catenin/Slug-mediated epithelial-to-mesenchymal transition. Which demonstrate that DSG2 is a valuable PSC surface marker that is essential for the maintenance of PSC self-renewal.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
122,294 Da
NCBI Official Full Name
desmoglein-2 preproprotein
NCBI Official Synonym Full Names
desmoglein 2
NCBI Official Symbol
DSG2
NCBI Official Synonym Symbols
HDGC; CDHF5; ARVC10; ARVD10; CMD1BB
NCBI Protein Information
desmoglein-2; HDGC; cadherin family member 5
UniProt Protein Name
Desmoglein-2
UniProt Gene Name
DSG2
UniProt Synonym Gene Names
CDHF5
UniProt Entry Name
DSG2_HUMAN
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Product Notes
The DSG2 dsg2 (Catalog #AAA259293) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Human Desmoglein-2 Protein (His Tag), HPLC-verified reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Ala50-Gly6 09. It is sometimes possible for the material contained within the vial of "Desmoglein-2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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