SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
DYRK1A recombinant protein
DYRK1A, Active
Gene Names
Dyrk1a; Dyrk; PSK47
Applications
Western Blot
Synonyms
DYRK1A; N/A; DYRK1A, Active; DYRK; PSK47; DYRK1A recombinant protein
Host
E Coli
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Applicable Applications for DYRK1A recombinant protein
WB (Western Blot), Kinase Assay
Tag
GST
Species
Rat
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
Related Product Information for DYRK1A recombinant protein
Recombinant full-length rat DYRK1A was expressed in E Coli cells using an N-terminal GST tag. The protein accession number is Q63470-2.
DYRK1 A or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family which contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. DYRK1A participates in various cellular processes. DYRK1A is a highly conserved gene located in the so-called Down Syndrome critical region (DSCR) on part of chromosome 21 that is responsible for the majority of phenotypic features in Down syndrome (1). DYRK1A plays a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is also contributing to early onset of Alzheimer disease (2).
DYRK1 A or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family which contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. DYRK1A participates in various cellular processes. DYRK1A is a highly conserved gene located in the so-called Down Syndrome critical region (DSCR) on part of chromosome 21 that is responsible for the majority of phenotypic features in Down syndrome (1). DYRK1A plays a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is also contributing to early onset of Alzheimer disease (2).
Product Categories/Family for DYRK1A recombinant protein
References
1. van Bon, B. et al: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly. Clin. Genet. 79: 296-299, 2011.
2. Ryoo, S. R. et al: DYRK1A-mediated hyperphosphorylation of tau: a functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282: 34850-34857, 2007.
2. Ryoo, S. R. et al: DYRK1A-mediated hyperphosphorylation of tau: a functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282: 34850-34857, 2007.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39.4 kDa (343 aa)
NCBI Official Full Name
dual specificity tyrosine-phosphorylation-regulated kinase 1A
NCBI Official Synonym Full Names
dual specificity tyrosine phosphorylation regulated kinase 1A
NCBI Official Symbol
Dyrk1a
NCBI Official Synonym Symbols
Dyrk; PSK47
NCBI Protein Information
dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt Protein Name
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt Gene Name
Dyrk1a
UniProt Synonym Gene Names
Dyrk; MNBH
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Product Notes
The DYRK1A dyrk1a (Catalog #AAA73397) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DYRK1A can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), Kinase Assay. Researchers should empirically determine the suitability of the DYRK1A dyrk1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DYRK1A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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