Purity Data
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COVID 19 RdRp Coronavirus Active Protein | COVID-19 active protein
2019-nCoV RdRp, Active
Synonyms
COVID 19 RdRp Coronavirus; N/A; 2019-nCoV RdRp, Active; 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; RdRp; COVID-19 active protein
Host
E Coli
Form/Format
50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole, 1mM DTT, 10% glycerol
Species
SARS-CoV-2
Tag
HIS
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity Data
(Sample Purity Data.)
Purity Data
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Specific Activity
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Specific Activity
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Related Product Information for COVID-19 active protein
Recombinant 2019-nCoV RNA-dependent RNA polymerase (RdRp) was expressed in E Coli cells using a C-terminal His tag.
Overview: A novel Corona virus (SARS-CoV-2) has caused a global COVID-19 pandemic of respiratory disease in 2020 (1). RNA-dependent RNA polymerase (RdRp) is an enzyme that is crucial to life cycle of RNA viruses including Corona viruses (2). RdRp catalyzes the synthesis of viral RNA, thereby playing a central role in the replication and transcription cycle of COVID-19 viruses, possibly in complex with nsp7 and nsp8 (3). Therefore, RdRp is a prime target for nucleotide analog antiviral inhibitors, such as remedesivir, for development of new antiviral therapeutics (4).
Overview: A novel Corona virus (SARS-CoV-2) has caused a global COVID-19 pandemic of respiratory disease in 2020 (1). RNA-dependent RNA polymerase (RdRp) is an enzyme that is crucial to life cycle of RNA viruses including Corona viruses (2). RdRp catalyzes the synthesis of viral RNA, thereby playing a central role in the replication and transcription cycle of COVID-19 viruses, possibly in complex with nsp7 and nsp8 (3). Therefore, RdRp is a prime target for nucleotide analog antiviral inhibitors, such as remedesivir, for development of new antiviral therapeutics (4).
Product Categories/Family for COVID-19 active protein
References
1. Zhou P, et al: A pneumonia outbreak associated with a new Corona virus of probable bat origin. Nature. 2020, 579:270-89
2. Subissi L, et al: One severe acute respiratory syndrome Corona virus protein complex integrates processive RNA polymerase and exonuclease activities. Proc. Natl. Acad. Sci. U.S.A. 2014, 111: E3900-E3909.
3. Gao Y, et al: Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 2020, 368: 779-782.
4. Wang M, et al: Remdesivir and chloroquine effectively inhibit the recently emerged novel Corona virus (2019-nCoV) in vitro. Cell Res. 2020, 30:269-271.
2. Subissi L, et al: One severe acute respiratory syndrome Corona virus protein complex integrates processive RNA polymerase and exonuclease activities. Proc. Natl. Acad. Sci. U.S.A. 2014, 111: E3900-E3909.
3. Gao Y, et al: Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 2020, 368: 779-782.
4. Wang M, et al: Remdesivir and chloroquine effectively inhibit the recently emerged novel Corona virus (2019-nCoV) in vitro. Cell Res. 2020, 30:269-271.
NCBI and Uniprot Product Information
Molecular Weight
~100kDa
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Product Notes
The COVID-19 (Catalog #AAA73171) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "COVID 19 RdRp Coronavirus, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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