CYR61 active protein
Human CYR61
Gene Names
CYR61; CCN1; GIG1; IGFBP10
Reactivity
Human
Purity
> 95% by SDS-PAGE and HPLC analysis
Synonyms
CYR61; N/A; Human CYR61; Recombinant Human CYR61; CYR61 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 95% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized from 10 mM Sodium Citrate, pH 3.0 + 50mM NaCl
Sequence
MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQP CDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF Q PNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEE WVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GS SLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRV TN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPV RFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGET F SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD
Sequence Length
381
Endotoxin Level
< 0.1 ng per ug of CYR61
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 ug/ml
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Preparation and Storage
The lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 5 months at -20 degree C to -80 degree C. Avoid repeated freeze thaw cycles.
Related Product Information for CYR61 active protein
CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Product Categories/Family for CYR61 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,5 kDa
NCBI Official Full Name
protein CYR61
NCBI Official Synonym Full Names
cysteine-rich, angiogenic inducer, 61
NCBI Official Symbol
CYR61
NCBI Official Synonym Symbols
CCN1; GIG1; IGFBP10
NCBI Protein Information
protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10
UniProt Protein Name
Protein CYR61
UniProt Gene Name
CYR61
UniProt Synonym Gene Names
CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10
UniProt Entry Name
CYR61_HUMAN
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Product Notes
The CYR61 cyr61 (Catalog #AAA79141) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human CYR61 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQP CDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF Q PNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEE WVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GS SLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRV TN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPV RFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGET F SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD. It is sometimes possible for the material contained within the vial of "CYR61, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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