Galectin-1 (LGALS1) Active Protein | LGALS1 active protein

Recombinant Human Galectin-1 (LGALS1)

Cat. Num. AAA214275

• Gene Names: LGALS1; GBP; GAL1
• Reactivity: Human (H. sapiens)
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Galectin-1 (LGALS1); N/A; Recombinant Human Galectin-1 (LGALS1); Beta-Galactoside-Binding Lectin L-14-I; Gal-1; 14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein PM12; S-Lac lectin 1; LGALS1 active protein

• Host: E Coli
• Reactivity: Human (H. sapiens)
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS and 2-ME with BSA as a carrier protein.
• Sequence Length: 135

• Bioactivity: Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 0.53 ug/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: Reconstitute at 100 ug/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Application Data

Application Data

Related Product Information for LGALS1 active protein

Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.

NCBI and Uniprot Product Information

• NCBI GI #: 4504981
• NCBI GeneID: 3956
• NCBI Accession #: NP_002296.1
• NCBI GenBank Nucleotide #: NP_002296.1
• UniProt Accession #: P09382
• Molecular Weight: 14.9 kDa
• NCBI Official Full Name: galectin-1
• NCBI Official Synonym Full Names: galectin 1
• NCBI Official Symbol: LGALS1
• NCBI Official Synonym Symbols: GBP; GAL1
• NCBI Protein Information: galectin-1
• UniProt Protein Name: Galectin-1
• UniProt Gene Name: LGALS1
• UniProt Synonym Gene Names: Gal-1; HLBP14
• UniProt Entry Name: LEG1_HUMAN