Neurturin Active Protein | NRTN active protein
Human Neurturin
Gene Names
NRTN; NTN
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
Neurturin; N/A; Human Neurturin; Recombinant Human Neurturin; NRTN active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized from 10 mM Sodium Citrate, pH 4.0
Sequence
ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVY DLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT V HELSARECA CV
Sequence Length
197
Structural Information
disulphide-linked homodimer
Endotoxin Level
< 0.1 ng/ug per ug of protein
Biological Activity
Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
Length (aa)
204
Stability
The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C
Reconstitution
Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2°C to 8°C gor up to 1 week. For extended storage , it is recommended to further dilute in a buffer containing a carrier protien (example 0.1% BSA) and store in working aliquots at -20C to -80°C.
Preparation and Storage
Store at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C
Related Product Information for NRTN active protein
Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRalpha2. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Product Categories/Family for NRTN active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
11.8 kDa
NCBI Official Full Name
neurturin preproprotein
NCBI Official Synonym Full Names
neurturin
NCBI Official Symbol
NRTN
NCBI Official Synonym Symbols
NTN
NCBI Protein Information
neurturin; prepro-neurturin
UniProt Protein Name
Neurturin
UniProt Gene Name
NRTN
UniProt Entry Name
NRTN_HUMAN
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Product Notes
The NRTN nrtn (Catalog #AAA79278) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Neurturin reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVY DLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT V HELSARECA CV. It is sometimes possible for the material contained within the vial of "Neurturin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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