NNT-1/BCSF-3 active protein
Human NNT-1/BCSF-3
Gene Names
CLCF1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
NNT-1/BCSF-3; N/A; Human NNT-1/BCSF-3; Recombinant Human NNT-1/BCSF-3; NNT-1/BCSF-3 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEP DFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY L RGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLP GTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KK MQPPAAAV TLHLGAHGF
Sequence Length
215
Length (aa)
199
Endotoxin Level
< 0.1 ng per ug of protein (<1EU/ug)
Biological Activity
NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/m
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1 -1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at 20°C to -80°C.
Preparation and Storage
The lyophilized protein is stable at room tempeture for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C. Avoid repeated freeze thaw cycles.
Related Product Information for NNT-1/BCSF-3 active protein
NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM. Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.
Product Categories/Family for NNT-1/BCSF-3 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
22.4 kDa
NCBI Official Full Name
cardiotrophin-like cytokine factor 1 isoform 2
NCBI Official Synonym Full Names
cardiotrophin-like cytokine factor 1
NCBI Official Symbol
CLCF1
NCBI Official Synonym Symbols
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
NCBI Protein Information
cardiotrophin-like cytokine factor 1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3
UniProt Protein Name
Cardiotrophin-like cytokine factor 1
UniProt Gene Name
CLCF1
UniProt Synonym Gene Names
BSF3; CLC; NNT1; BSF-3; NNT-1
UniProt Entry Name
CLCF1_HUMAN
Similar Products
Product Notes
The NNT-1/BCSF-3 clcf1 (Catalog #AAA79298) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human NNT-1/BCSF-3 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEP DFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY L RGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLP GTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KK MQPPAAAV TLHLGAHGF. It is sometimes possible for the material contained within the vial of "NNT-1/BCSF-3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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