SDS-PAGE
GFRA3 / GFR-alpha-3 Recombinant Protein | GFRA3 recombinant protein
Recombinant Human GFRA3 / GFR-alpha-3 Protein (His tag)
Gene Names
GFRA3; GDNFR3
Purity
> 90 % as determined by reducing SDS-PAGE.
Synonyms
GFRA3 / GFR-alpha-3; N/A; Recombinant Human GFRA3 / GFR-alpha-3 Protein (His tag); GDNFR3; GFRA3 recombinant protein
Host
HEK293 Cells
Purity/Purification
> 90 % as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4, 5% Trehalose, 5% Mannitol, 0.01% Tween-80.
Sequence
Met 1-Trp 382
Sequence Length
400
Species
Human
Endotoxin
< 1.0 EU per ug as determined by the LAL method.
Tag
C-His
Reconstitution
It is recommended that sterile water(500ul) be added to the vial to prepare a stock solution of 0.1mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
SDS-PAGE
SDS-PAGE
Related Product Information for GFRA3 recombinant protein
Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell linederived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor ?3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Mol_Mass: 40.8 kDa
AP_Mol_Mass: 50 kDa
AP_Mol_Mass: 50 kDa
NCBI Official Full Name
GDNF family receptor alpha-3 preproprotein
NCBI Official Synonym Full Names
GDNF family receptor alpha 3
NCBI Official Symbol
GFRA3
NCBI Official Synonym Symbols
GDNFR3
NCBI Protein Information
GDNF family receptor alpha-3
UniProt Protein Name
GDNF family receptor alpha-3
UniProt Gene Name
GFRA3
UniProt Synonym Gene Names
GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3
Similar Products
Product Notes
The GFRA3 gfra3 (Catalog #AAA173571) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met 1-Trp 382. It is sometimes possible for the material contained within the vial of "GFRA3 / GFR-alpha-3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.