Growth Hormone Receptor Recombinant Protein | GHR recombinant protein

Recombinant Human Growth Hormone Receptor Protein (His Tag), HPLC-verified

Cat. Num. AAA259299

• Gene Names: GHR; GHBP
• Reactivity: Human
• Purity: >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC. >= 95% as determined by SEC-MALS. (Routinely tested)
• Synonyms: Growth Hormone Receptor; N/A; Recombinant Human Growth Hormone Receptor Protein (His Tag), HPLC-verified; Human Growth Hormone Receptor Protein (His Tag); growth hormone receptor; GHBP Protein, Human; GHIP Protein, Human; GHR recombinant protein

• Host: HEK293 Cells
• Reactivity: Human
• Purity/Purification: >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC. >= 95% as determined by SEC-MALS. (Routinely tested)
• Form/Format: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence: Ala27-Tyr264

• Tag: C-His
• Predicted N Terminal: Ala 27
• Endotoxin: < 1.0 EU perug of the protein as determined by the LAL method
• Protein Construction: A DNA sequence encoding the Human GHR (P10912)(Ala27-Tyr264) was expressed with a polyhistidine tag at the C-terminus.
• Activity: Immobilized Recombinant Human GH1 Protein at 2ug/mL (100uL/well) can bind Recombinant Human Growth Hormone Receptor Protein (His Tag), the EC50 is 4-15ng/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Application Data

(Recombinant Human Growth Hormone Receptor Protein,His Tag,HPLC-verified.)

Application Data

(Immobilized Recombinant Human GH1 Protein at 2ug/mL (100uL/well) can bind Recombinant Human Growth Hormone Receptor Protein (His Tag)(#AAA259299), the EC50 is 4-15ng/mL.)

Application Data

Application Data

Related Product Information for GHR recombinant protein

Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domain. Growth hormone receptor/GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform4of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform1 expression of GHR in placenta is predominant in chorion and decidua. Isoform4is highly expressed in placental villi. Isoform2of GHR is expressed in lung, stomach and muscle. Growth hormone receptor/GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2/STAT5 pathway. Isoform2of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

References

Leun. DW. e. al.. 1987. Nature. 330:537-43. Sobrie. M-L. e. al.. 1997. . Cli. Endocrino. Metab. 82. 435-7. Enber. B. e. al.. 2000. Eu. . Endocrinol. 143. 71-6. Pante. J. e. al.. 2000. . Bio. Chem. 275. 18664-9. Jorg. AAL. e. al.. 2004. Cli. Endocrinol. (Oxf.. 60. 36-40.

NCBI and Uniprot Product Information

• NCBI GI #: 4503993
• NCBI GeneID: 2690
• NCBI Accession #: NP_000154.1
• NCBI GenBank Nucleotide #: NM_000163.4
• UniProt Accession #: P10912; Q9HCX2
• Molecular Weight: 71,500 Da
• NCBI Official Full Name: growth hormone receptor isoform 1
• NCBI Official Synonym Full Names: growth hormone receptor
• NCBI Official Symbol: GHR
• NCBI Official Synonym Symbols: GHBP
• NCBI Protein Information: growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
• UniProt Protein Name: Growth hormone receptor
• UniProt Gene Name: GHR
• UniProt Synonym Gene Names: GH receptor; GH-binding protein; GHBP
• UniProt Entry Name: GHR_HUMAN