SDS-PAGE
Ganglioside GM2 Activator Recombinant Protein | GM2A recombinant protein
Recombinant Human GM2A Protein (Human Cells, His Tag)
Gene Names
GM2A; SAP-3; GM2-AP
Purity
>95 % as determined by reducing SDS-PAGE.
Synonyms
Ganglioside GM2 Activator; N/A; Recombinant Human GM2A Protein (Human Cells, His Tag); Ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3 Human; GM2A recombinant protein
Purity/Purification
>95 % as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH7.5.
Sequence
Ser32 - Ile193
Species
Human Cells
Tag
C-6His
Endotoxin
< 1.0 EU per ug as determined by the LAL method.
Reconstitution
We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex.
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
SDS-PAGE
SDS-PAGE
Related Product Information for GM2A recombinant protein
Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A (HEXB). HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Mol Mass: 18.6 kDa
AP Mol Mass: 19-22 kDa
AP Mol Mass: 19-22 kDa
NCBI Official Full Name
ganglioside GM2 activator isoform 1
NCBI Official Synonym Full Names
GM2 ganglioside activator
NCBI Official Symbol
GM2A
NCBI Official Synonym Symbols
SAP-3; GM2-AP
NCBI Protein Information
ganglioside GM2 activator
UniProt Protein Name
Ganglioside GM2 activator
UniProt Gene Name
GM2A
UniProt Synonym Gene Names
SAP-3
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Product Notes
The GM2A gm2a (Catalog #AAA22124) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Ser32 - Ile193. It is sometimes possible for the material contained within the vial of "Ganglioside GM2 Activator, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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