Application Data
GOPC-ROS1 recombinant protein
GOPC-ROS1 Mutant, Active
Gene Names
GOPC; CAL; FIG; PIST; GOPC1; dJ94G16.2
Applications
Kinase Assay
Synonyms
GOPC-ROS1; N/A; GOPC-ROS1 Mutant, Active; GOPC-ROS1 recombinant protein
Host
Sf9 insect cells using baculovirus
Form/Format
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Sequence Positions
1-419 (GOPC) - 1881-end (ROS1)
Sequence Length
4640
Applicable Applications for GOPC-ROS1 recombinant protein
Kinase Assay
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for GOPC-ROS1 recombinant protein
Description: Recombinant human fusion protein GOPC (1-419)-ROS1 (1881-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: GOPC gene encodes a Golgi protein with a PDZ domain. Mice which are deficient in the GOPC protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms of GOPC have been found for this gene and GOPC gene locus is involved in translocations with other loci including c-ros oncogene 1 (ROS1) which result in the formation of the GOPC-ROS1 fusion protein that act as an oncogene. The ros1 gene encodes a proto-oncogenic protein which has been implicated in the pathogenesis of several types of cancer, including lung cancer and gliomas (1). GOPC-ROS1 fusion gene product has been identified in lung cancer (2).
Scientific Background: GOPC gene encodes a Golgi protein with a PDZ domain. Mice which are deficient in the GOPC protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms of GOPC have been found for this gene and GOPC gene locus is involved in translocations with other loci including c-ros oncogene 1 (ROS1) which result in the formation of the GOPC-ROS1 fusion protein that act as an oncogene. The ros1 gene encodes a proto-oncogenic protein which has been implicated in the pathogenesis of several types of cancer, including lung cancer and gliomas (1). GOPC-ROS1 fusion gene product has been identified in lung cancer (2).
Product Categories/Family for GOPC-ROS1 recombinant protein
References
1. Maxwell, M. et al: Overexpression of the ros1 gene in primary human gliomas may contribute to malignant progression. Int J Oncol. 1996 Apr;8 (4):713-8. 2. Suehara Y. et al: Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res. 2012 Dec 15;18 (24):6599-608.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
145 kDa
NCBI Official Full Name
Homo sapiens golgi associated PDZ and coiled-coil motif containing (GOPC), transcript variant 1, mRNA
NCBI Official Synonym Full Names
golgi associated PDZ and coiled-coil motif containing
NCBI Official Symbol
GOPC
NCBI Official Synonym Symbols
CAL; FIG; PIST; GOPC1; dJ94G16.2
NCBI Protein Information
Golgi-associated PDZ and coiled-coil motif-containing protein
UniProt Protein Name
Golgi-associated PDZ and coiled-coil motif-containing protein
UniProt Gene Name
GOPC
UniProt Synonym Gene Names
CAL; FIG; PIST
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Product Notes
The GOPC-ROS1 gopc (Catalog #AAA73116) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-419 (GOPC) - 1881-end (ROS1). AAA Biotech's GOPC-ROS1 can be used in a range of immunoassay formats including, but not limited to, Kinase Assay. Researchers should empirically determine the suitability of the GOPC-ROS1 gopc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GOPC-ROS1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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