TMIGD2/CD28H active protein

Recombinant human TMIGD2/CD28H protein

Cat. Num. AAA48995

• Gene Names: TMIGD2; CD28H; IGPR1; IGPR-1
• Applications: SDS-Page
• Purity: 95% by SDS-PAGE
• Synonyms: TMIGD2/CD28H; N/A; Recombinant human TMIGD2/CD28H protein; TMIGD2; Transmembrane and immunoglobulin domain-containing protein 2 isoform1; CD28 homolog; CD28H; Immunoglobulin and proline-rich receptor 1; IGPR-1; IGPR1; TMIGD2/CD28H active protein

• Host: HEK293
• Purity/Purification: 95% by SDS-PAGE
• Form/Format: Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 1mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence Positions: 23-150aa
• Sequence: Leu 23; LSVQQGPNLL QVRQGSQATL VCQVDQATAW ERLRVKWTKD GAILCQPYIT NGSLSLGVCG PQGRLSWQAP SHLTLQLDPV SLNHSGAYVC WAAVEIPELE EAEGNITRLF VDPDDPTQNR NRIASFPG

• Applicable Applications for TMIGD2/CD28H active protein: Bioactivity, SDS-PAGE
• Species: Human
• Endotoxin: <1 EU per 1ug of protein (determined by LAL method)
• Tag: hIgG-Tag
• Preparation and Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Related Product Information for TMIGD2/CD28H active protein

TMIGD2, also known as IGPR-1, is a member of the Immunoglobulin family. This protein shares approximately 10% amino acid sequence identity with CD28, CTLA-4, ICOS, and PD-1. The immunoglobulin domain of TMIGD2 was predicted to be Ig V fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein. It plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, co-stimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. It is constitutively expressed on naive T and NK cells. Similar to the interaction of B7 with CD28, the interaction of TMIGD2 with B7-H7 activates the Akt-dependent signaling cascade and promotes the proliferation and activation of newly generated peripheral effector and memory T cells. Also, it interacts with multiple cytoskeletal proteins. Recombinant human TMIGD2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Categories/Family for TMIGD2/CD28H active protein

Immunology, Cell Cycle, Other; Proteins

References

Rahimi N, et al. (2012) Mol. Biol. Cell 23:1646-1656.
Parry, R.V. et al. (2003) J.Immunol. 171:166-174.

NCBI and Uniprot Product Information

• NCBI GI #: 281306838
• NCBI GeneID: 126259
• NCBI Accession #: NP_653216.2
• NCBI GenBank Nucleotide #: NM_144615.2
• UniProt Accession #: Q96BF3; Q6UW59
• Molecular Weight: 30,319 Da
• NCBI Official Full Name: transmembrane and immunoglobulin domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: transmembrane and immunoglobulin domain containing 2
• NCBI Official Symbol: TMIGD2
• NCBI Official Synonym Symbols: CD28H; IGPR1; IGPR-1
• NCBI Protein Information: transmembrane and immunoglobulin domain-containing protein 2
• UniProt Protein Name: Transmembrane and immunoglobulin domain-containing protein 2
• UniProt Gene Name: TMIGD2
• UniProt Synonym Gene Names: CD28H; IGPR1; IGPR-1
• UniProt Entry Name: TMIG2_HUMAN