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Application Data
(Recombinant Human TNFRSF10B inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 30-120 pg/mL in the presence of 20 ng/mL Recombinant Human TRAIL/TNFSF10.)
TNFRSF10B/DR5/TRAIL-R2 active protein
Active Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein
Gene Names
TNFRSF10B; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
Purity
> 95% by SDS-PAGE.
Synonyms
TNFRSF10B/DR5/TRAIL-R2; N/A; Active Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein; CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9; TNFRSF10B; TNFRSF10B/DR5/TRAIL-R2 active protein
Host
HEK293 cells
Purity/Purification
> 95% by SDS-PAGE.
Form/Format
Liquid
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Species
Human
Tag
C-hFc&His
Bioactivity
1. Measured by its binding ability in a functional ELISA. Immobilized Human TNFRSF10B at 1 ug/mL (100 uL/well) can bind Human TNFSF10 with a linear range of 0.1-11.7 ng/mL.
2. Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L 929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 30-120 pg/mL in the presence of 20 ng/mL Recombinant Human TRAIL/TNFSF10.
2. Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L 929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 30-120 pg/mL in the presence of 20 ng/mL Recombinant Human TRAIL/TNFSF10.
Preparation and Storage
Store the lyophilized protein at -20 to -80 degree C for 12 months. After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week. Avoid repeated freeze/thaw cycles.
Ship: Ice Pack
Ship: Ice Pack
Application Data
(Recombinant Human TNFRSF10B inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 30-120 pg/mL in the presence of 20 ng/mL Recombinant Human TRAIL/TNFSF10.)
Application Data
(Recombinant Human TNFRSF10B inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 30-120 pg/mL in the presence of 20 ng/mL Recombinant Human TRAIL/TNFSF10.)
Application Data
(Immobilized Human TNFRSF10B at 1 ug/mL (100 uL/well) can bind Human TNFSF10 with a linear range of 0.1-11.7 ng/mL.)
Application Data
(Immobilized Human TNFRSF10B at 1 ug/mL (100 uL/well) can bind Human TNFSF10 with a linear range of 0.1-11.7 ng/mL.)
Application Data
(The purity of Human DR5/TRAIL R2 Protein (#AAA282494) was greater than 90% as determined by SEC-HPLC.)
Application Data
(The purity of Human DR5/TRAIL R2 Protein (#AAA282494) was greater than 90% as determined by SEC-HPLC.)
SDS-PAGE
(Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 50kDa.)
SDS-PAGE
(Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 50kDa.)
Related Product Information for TNFRSF10B/DR5/TRAIL-R2 active protein
Active Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile56-Glu182) of human DR5/TRAIL R2 (Accession #NP_003833.3) fused with a Fc, 6×His tag at the C-terminus.
Product Categories/Family for TNFRSF10B/DR5/TRAIL-R2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,878 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10B isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 10b
NCBI Official Symbol
TNFRSF10B
NCBI Official Synonym Symbols
DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10B
UniProt Gene Name
TNFRSF10B
UniProt Synonym Gene Names
DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2
UniProt Entry Name
TR10B_HUMAN
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Product Notes
The TNFRSF10B/DR5/TRAIL-R2 tnfrsf10b (Catalog #AAA282494) is an Active Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TNFRSF10B/DR5/TRAIL-R2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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