Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Human CD21 His at 2 ug/ml (100 ul/well) can bind Human Annexin VI/ANXA6 His, Biotinylated, the EC50 of Human Annexin VI/ANXA6 His, Biotinylated is 250-900 ng/mL.)
CD21 Active Protein | CR2 active protein
CD21 Protein, Human, Recombinant (His Tag)
Gene Names
CR2; CR; C3DR; CD21; CVID7; SLEB9
Purity
>95% as determined by SDS-PAGE
Synonyms
CD21; N/A; CD21 Protein, Human, Recombinant (His Tag); Human CD21/CR2/C3DR Protein (His Tag); C3DR Protein, Human; CD21 Protein, Human; CR Protein, Human; CVID7 Protein, Human; SLEB9 Protein, Human; complement component (3d/Epstein Barr virus) receptor 2; CR2 active protein
Host
HEK293 Cells
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Arg971
Species
Human
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Ile 21
Tag
C-His
Protein Construction
A DNA sequence encoding the human CD21 isoform A (P20023-1) extracellular domain (Met 1-Arg 971) was expressed, with a carboxy-terminal polyhistidine tag.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD21 His at 2ug/ml (100uL/well) can bind Human Annexin VI/ANXA6 His, Biotinylated. The EC50 of Human Annexin VI/ANXA6 His, Biotinylated is 250-900ng/mL.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Human CD21 His at 2 ug/ml (100 ul/well) can bind Human Annexin VI/ANXA6 His, Biotinylated, the EC50 of Human Annexin VI/ANXA6 His, Biotinylated is 250-900 ng/mL.)
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Human CD21 His at 2 ug/ml (100 ul/well) can bind Human Annexin VI/ANXA6 His, Biotinylated, the EC50 of Human Annexin VI/ANXA6 His, Biotinylated is 250-900 ng/mL.)
SDS-PAGE
SDS-PAGE
Related Product Information for CR2 active protein
Background: The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD21, also known as Complement component (3d/Epstein Barr virus) receptor 2 and CR2, is a member of the CD system and is a protein involved in complement system. CD21 is present on all mature B-cells and some T-cells and follicular dendritic cells. CD21 on mature B-cells form a complex called the B cell receptor complex with two other membrane proteins, CD19 and CD81. CD21 has a function in the complement system through serving as the cellular receptor specific for ligands such as C3 and C4 which can be attached to foreign macromolecules in order to remove or uptake them. This results in B-cells having enhanced response to the antigen.
Product Categories/Family for CR2 active protein
References
Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.Joseph M, et al. (1989) Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21). Advanced in immunology. 46: 183-219.Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature 358: 505 - 7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Complement receptor type 2
NCBI Official Synonym Full Names
complement C3d receptor 2
NCBI Official Symbol
CR2
NCBI Official Synonym Symbols
CR; C3DR; CD21; CVID7; SLEB9
NCBI Protein Information
complement receptor type 2
UniProt Protein Name
Complement receptor type 2
UniProt Gene Name
CR2
UniProt Synonym Gene Names
C3DR; Cr2; EBV receptor
UniProt Entry Name
CR2_HUMAN
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Product Notes
The CR2 cr2 (Catalog #AAA257931) is an Active Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Arg97 1. It is sometimes possible for the material contained within the vial of "CD21, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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