Bioactivity
(Bioactivity & antigenicity: Strong binding ability with human ACE2 protein and binding capacity to a human anti-S1 monoclonal antibody (determined by ELISA).)
COVID 19 Spike 1 Receptor-Binding Domain (S1RBD) Coronavirus Active Protein | COVID-19 active protein
Receptor-Binding Domain (S1RBD)
Purity
>95%
Synonyms
COVID 19 Spike 1 Receptor-Binding Domain (S1RBD) Coronavirus; N/A; Receptor-Binding Domain (S1RBD); 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike 1 Receptor-Binding Domain (S1RBD); Receptor Binding Domain; COVID-19 active protein
Host
HEK293
Purity/Purification
>95%
Form/Format
The protein is lyophilized in PBS, PH 7.4. Add appropriate volume of PBS into the tube and let the pellet dissolve completely. For example, adding 100 ul of PBS to make a final concentration of 1 mg/ml.
Tag Information
His at C-terminus
Endotoxin
<5 EU/mg, determined by the LAL method
Bioactivity & antigenicity
Strong binding ability with human ACE2 protein and binding capacity to a human anti-S1RBD monoclonal antibody (determined by ELISA).
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -80 degree C. Recommend to aliquot the protein into smaller quantities. Avoid repeated freeze-thaw cycles.
Ships on dry ice.
Ships on dry ice.
Bioactivity
(Bioactivity & antigenicity: Strong binding ability with human ACE2 protein and binding capacity to a human anti-S1 monoclonal antibody (determined by ELISA).)
Bioactivity
(Bioactivity & antigenicity: Strong binding ability with human ACE2 protein and binding capacity to a human anti-S1 monoclonal antibody (determined by ELISA).)
SDS-PAGE
(Recombinant SARS-CoV-2 Spike Protein (RBD) consists of 234 amino acids (Arg319-Phe541) with C-terminal His-tag. It has an apparent molecular mass of ~25 kDa in SDS-PAGE. The concentration of protein was determined by BCA.)
SDS-PAGE
(Recombinant SARS-CoV-2 Spike Protein (RBD) consists of 234 amino acids (Arg319-Phe541) with C-terminal His-tag. It has an apparent molecular mass of ~25 kDa in SDS-PAGE. The concentration of protein was determined by BCA.)
Related Product Information for COVID-19 active protein
Recombinant SARS-CoV-2 Spike Protein (RBD) consists of 234 amino acids (Arg319-Phe541) with C-terminal His-tag. It has an apparent molecular mass of ~25 kDa in SDS-PAGE. The concentration of protein was determined by BCA.
The SARS-CoV-2 glycosylated spike (S) protein highly exposed on the viral surface is a major determinant for virus binding and invasion into hose cells, which is a main target for neutralization antibody. The receptor-binding domain (RBD) in SARS-CoV-2 S protein is responsible for binding to human and bat angiotensin-converting enzyme 2 (ACE2) receptors.
The SARS-CoV-2 glycosylated spike (S) protein highly exposed on the viral surface is a major determinant for virus binding and invasion into hose cells, which is a main target for neutralization antibody. The receptor-binding domain (RBD) in SARS-CoV-2 S protein is responsible for binding to human and bat angiotensin-converting enzyme 2 (ACE2) receptors.
References
Shajahan A, et al. (2020) Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2. bioRxiv, https://doi.org/10.1101/2020.04.01.020966.
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Product Notes
The COVID-19 (Catalog #AAA60538) is an Active Protein produced from HEK293 and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is His at C-terminus!!Endotoxin||<5 EU/mg, determined by the LAL method. It is sometimes possible for the material contained within the vial of "COVID 19 Spike 1 Receptor-Binding Domain (S1RBD) Coronavirus, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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