PDGF CC active protein
PDGF CC protein
Gene Names
PDGFC; SCDGF; FALLOTEIN
Purity
> 98% pure
Synonyms
PDGF CC; N/A; PDGF CC protein; Osteosarcoma-derived Growth Factor protein; Platelet-Derived Growth Factor-CC protein; ODGF protein; Glioma-derived growth factor protein; PCGF protein; GDGF protein; PDGF CC active protein
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder.
Sequence
Region of PDGF CC protein corresponding to amino acids MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG.
Sequence Length
345
Protein Type
Recombinant
Biological Significance
The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-a and PDGFR-beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells.
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for PDGF CC active protein
Purified recombinant Human PDGF CC protein
Product Categories/Family for PDGF CC active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
20,609 Da
NCBI Official Full Name
Platelet-derived growth factor C
NCBI Official Synonym Full Names
platelet derived growth factor C
NCBI Official Symbol
PDGFC
NCBI Official Synonym Symbols
SCDGF; FALLOTEIN
NCBI Protein Information
platelet-derived growth factor C
UniProt Protein Name
Platelet-derived growth factor C
UniProt Gene Name
PDGFC
UniProt Synonym Gene Names
SCDGF; PDGF-C; SCDGF; PDGFC latent form; PDGFC receptor-binding form
UniProt Entry Name
PDGFC_HUMAN
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Product Notes
The PDGF CC pdgfc (Catalog #AAA75572) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Region of PDGF CC protein correspond ing to amino acids MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG. It is sometimes possible for the material contained within the vial of "PDGF CC, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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