anti-Human LOX1 Antibody | anti-LOX1 antibody

Anti-Hu LOX1 Purified

Cat. Num. AAA129206

• Gene Names: OLR1; LOX1; LOXIN; SLOX1; CLEC8A; SCARE1
• Reactivity: Human
• Applications: Immunohistochemistry, Flow Cytometry, Functional Assay, Immunocytochemistry
• Synonyms: LOX1; N/A; Anti-Hu LOX1 Purified; oxidized low density lipoprotein receptor 1; OLR1; SLOX1; SCARE1; CLEC8A; anti-LOX1 antibody

• Reactivity: Human
• Isotype: Mouse IgG2a kappa
• Clone Number: 15C4
• Specificity: The mouse monoclonal antibody 15C4 recognizes an extracellular epitope of LOX1, a C-type lectin transmembrane protein.
• Form/Format: Purified; Purified by protein-A affinity chromatography.; Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-LOX1 antibody: IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry), ICC (Immunocytochemistry)
• Immunogen: fusion protein of human LOX1 ectodomain and of human IgG Fc
• Preparation and Storage: Store at 2-8 degree C. Do not freeze.

FCM/FACS (Flow Cytometry)

(Separation of human dendritic cells (red-filled) from human lymphocytes (black-dashed) in flow cytometry analysis (surface staining) stained using anti-human LOX1 (15C4) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)

FCM/FACS (Flow Cytometry)

(Flow cytometry surface staining pattern of human dendritic cells in flow cytometry analysis (surface staining) stained using anti-human LOX1 (15C4) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)

Related Product Information for anti-LOX1 antibody

LOX1, a 31 kDa type II transmembrane protein, is a C-type lectin, functioning as a scavenger receptor for e.g. oxidized low density lipoprotein, apoptotic heat shock proteins, or CRP. It is expressed by macrophages, fibroblasts, platelets, endothelial cells, and smooth muscle cells, and its defects can lead to atherosclerosis. Its expression is enhanced under inflammatory conditions. Multiple splicing variants have been identified.

References

*Duluc D, Banchereau R, Gannevat J, Thompson-Snipes L, Blanck JP, Zurawski S, Zurawski G, Hong S, Urgell JR, Pascual V, Baldwin N, Stecher J, Carley M, Boreham M, Oh S: Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments. Genome Med. 2014 Nov 25;6(11):98., URL: https://pubmed.ncbi.nlm.nih.gov/25520755/,*Cassetta L, Bruderek K, Skrzeczynska J, Osiecka O, Hu X, Rundgren IM, Lin A, Santegoets K, Horzum U, Godinho-Santos A, Zelinsky G, Garcia-Tellez T, Bjelica S, Taciak B, Kittang AO, Höing B, Lang S, Dixon M, Müller V, Utíkal JS, Karakoç D, Yilmaz KB, Górka E, Bodnár L, Anastasiou OE, Bourgeois C, Ba?ura R, Kapinska-Mrowiecka M, Gotic M, Laan MT, Kers-Rebel E, Król M, Santibañez JF, Müller M, Dittmer U, de Sousa AE, Esenda?li G, Adema G, Loré K, Ersvær E, Umansky V, Pollard JW, Cichy J, Brandau S: Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation. J Immunother Cancer. 2020 Sep;8(2):e001223., URL: https://pubmed.ncbi.nlm.nih.gov/32907925/,*Joo H, Li D, Dullaers M, Kim TW, Duluc D, Upchurch K, Xue Y, Zurawski S, Le Grand R, Liu YJ, Kuroda M, Zurawski G, Oh S: C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. Immunity 2014 Oct 16;41(4):592-604., URL: https://pubmed.ncbi.nlm.nih.gov/25308333/,*Bayik D, Zhou Y, Park C, Hong C, Vail D, Silver DJ, Lauko A, Roversi G, Watson DC, Lo A, Alban TJ, McGraw M, Sorensen M, Grabowski MM, Otvos B, Vogelbaum MA, Horbinski C, Kristensen BW, Khalil AM, Hwang TH, Ahluwalia MS, Cheng F, Lathia JD: Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner. Cancer Discov. 2020 Aug;10(8):1210-1225., URL: https://pubmed.ncbi.nlm.nih.gov/32300059/,*Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J, Oh S: Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med. 2012 Jan 16;209(1):109-21., URL: https://pubmed.ncbi.nlm.nih.gov/22213806/,

NCBI and Uniprot Product Information

• NCBI GI #: 4505501
• NCBI GeneID: 4973
• NCBI Accession #: NP_002534.1
• NCBI GenBank Nucleotide #: NM_002543.3
• UniProt Accession #: P78380; Q2PP00; Q7Z484; A8K7V9; B4DI48; G3V1I4
• Molecular Weight: 30,959 Da
• NCBI Official Full Name: oxidized low-density lipoprotein receptor 1 isoform 1
• NCBI Official Synonym Full Names: oxidized low density lipoprotein (lectin-like) receptor 1
• NCBI Official Symbol: OLR1
• NCBI Official Synonym Symbols: LOX1; LOXIN; SLOX1; CLEC8A; SCARE1
• NCBI Protein Information: oxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type lectin domain family 8 member A; oxidized low-density lipoprotein receptor 1, soluble form
• UniProt Protein Name: Oxidized low-density lipoprotein receptor 1
• UniProt Gene Name: OLR1
• UniProt Synonym Gene Names: CLEC8A; LOX1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1
• UniProt Entry Name: OLR1_HUMAN