Human Complement C1S Subcomponent, C1S ELISA Kit | C1S elisa kit

Human Complement C1S Subcomponent, C1S Primacu ELISA Kit

Cat. Num. AAA124132

• Reactivity: Human
• Synonyms: Complement C1S Subcomponent, C1S; N/A; Human Complement C1S Subcomponent, C1S Primacu ELISA Kit; Complement C1s subcomponent; C1s; C1S elisa kit

• Reactivity: Human
• Assay Type: Sandwich
• Samples: Serum, plasma, cell culture supernates
• Detection Range: 93.75-6000pg/mL
• Sensitivity: 41.48pg/mL
• Standard Solution: 60ng/mL
• Assay Time: 3.5h

• Preparation and Storage: Store at 2-8 degree C

Standard Curve (Sample)

(Typical Testing Data/Standard Curve (for reference only))

Related Product Information for C1S elisa kit

Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complement, share similar overall structural organizations featuring five nonenzymic protein modules (two CUB modules surrounding a single EGF module, and a pair of CCP modules) followed by a serine protease domain. Besides highly specific proteolytic activities, both proteases exhibit interaction properties associated with their N-terminal regions. In contrast, C1r and C1s widely differ from each other by their glycosylation patterns: both proteins contain Asn-linked carbohydrates, but four glycosylation sites are present on C1r, and only two on C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. Like other complement serine proteases C1s has restricted substrate specificity and it is engaged into specific interactions with other subcomponents of the complement system. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.

Product Categories/Family for C1S elisa kit

Primacu ELISA Kit; Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 4502495
• NCBI GeneID: 716
• NCBI Accession #: NP_001725.1
• NCBI GenBank Nucleotide #: NM_001734.3
• UniProt Accession #: P09871; Q9UCU7; Q9UCU8; Q9UCU9; Q9UCV0; Q9UCV1; Q9UCV2; Q9UCV3; Q9UCV4; Q9UCV5; Q9UM14; D3DUT4
• Molecular Weight: 76,684 Da
• NCBI Official Full Name: complement C1s subcomponent
• NCBI Official Synonym Full Names: complement component 1, s subcomponent
• NCBI Official Symbol: C1S
• NCBI Protein Information: complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s
• UniProt Protein Name: Complement C1s subcomponent
• UniProt Gene Name: C1S
• UniProt Entry Name: C1S_HUMAN