Human Granulocyte-Macrophage Colony-Stimulating Factor, Csf2 ELISA Kit | Csf2 elisa kit

Human Granulocyte-Macrophage Colony-Stimulating Factor, Csf2 Primacu ELISA Kit

Cat. Num. AAA124408

• Gene Names: Csf2; Csfgm; GMCSF; Gm-CSf; MGI-IGM
• Reactivity: Human
• Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, Csf2; N/A; Human Granulocyte-Macrophage Colony-Stimulating Factor, Csf2 Primacu ELISA Kit; Granulocyte-macrophage colony-stimulating factor; GM-CSF; Csfgm; Csf2 elisa kit

• Reactivity: Human
• Assay Type: Sandwich
• Samples: Serum, plasma, cell culture supernates
• Detection Range: 9.38-600pg/mL
• Sensitivity: 4.47pg/mL
• Standard Solution: 4ng/mL
• Assay Time: 3.5h

• Preparation and Storage: Store at 2-8 degree C

Standard Curve (Sample)

(Typical Testing Data/Standard Curve (for reference only))

Related Product Information for Csf2 elisa kit

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy

Product Categories/Family for Csf2 elisa kit

Primacu ELISA Kit; Immunology; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 110625658
• NCBI GeneID: 12981
• NCBI Accession #: NP_034099.2
• NCBI GenBank Nucleotide #: NM_009969.4
• UniProt Accession #: P01587
• Molecular Weight: 16,091 Da
• NCBI Official Full Name: granulocyte-macrophage colony-stimulating factor
• NCBI Official Synonym Full Names: colony stimulating factor 2 (granulocyte-macrophage)
• NCBI Official Symbol: Csf2
• NCBI Official Synonym Symbols: Csfgm; GMCSF; Gm-CSf; MGI-IGM
• NCBI Protein Information: granulocyte-macrophage colony-stimulating factor; CSF; granulocyte-macrophage colony stimulating factor 2; put. GM-CSF
• UniProt Protein Name: Granulocyte-macrophage colony-stimulating factor
• UniProt Gene Name: Csf2
• UniProt Synonym Gene Names: Csfgm; GM-CSF; CSF
• UniProt Entry Name: CSF2_MOUSE