Standard Curve (Sample)
(Representative standard curve for IL-24 ELISA. IL-24 was diluted in serial two-fold steps in Sample Diluent.)
Human IL-24/MDA-7 ELISA Kit | IL-24/MDA-7 elisa kit
Human IL-24/MDA-7 ELISA KIT
Reactivity
Human
Synonyms
IL-24/MDA-7; N/A; Human IL-24/MDA-7 ELISA KIT; Human IL-24/MDA-7; IL-24/MDA-7 elisa kit
Reactivity
Human
Specificity
Natural and recombinant Human IL-24/MDA-7 Ligand
Assay Type
Solid Phase Sandwich ELISA
Samples
Cell culture supernatant, serum, plasma (EDTA, citrate, heparin)
Detection Range
62.5-4000pg/mL
Sensitivity
30pg/mL
Assay Time
3 hours
Sample Volume
20 uL
Detection Method
Colorimetric
Preparation and Storage
Store at 4 degree C
Standard Curve (Sample)
(Representative standard curve for IL-24 ELISA. IL-24 was diluted in serial two-fold steps in Sample Diluent.)
Standard Curve (Sample)
(Representative standard curve for IL-24 ELISA. IL-24 was diluted in serial two-fold steps in Sample Diluent.)
Related Product Information for IL-24/MDA-7 elisa kit
Interleukin 24 (IL-24), also known as mda7 (melanoma differentiation associated gene7), is a member of the IL10 family of helical cytokines. The IL-24 gene encodes a precursor protein of 207 amino acids (aa) that contains a 48 aa signal sequence and an 18 kDa, 158 aa mature segment. There are three potential Nlinked glycosylation sites, at least one of which is used. When secreted, IL-24 is a 3540 kDa phosphorylated glycoprotein that apparently can exist as either a monomer or dimer. It is suggested that glycosylation is essential for activity. Mature human IL-24 shares 69% aa sequence identity with mouse and rat IL-24. Human IL-24 is also active in rodent systems. Cells known to express IL-24 include B cells, CD4+ T cells, NK cells, lymph node dendritic cells, monocytes, melanocytes, and melanoma cells. Functionally, IL-24 has diverse activities. At low concentrations on monocytes, it induces type I proinflammatory cytokines such as IFN-g, IL-1b, IL-12, and TNF-a. At high concentrations, it is a strong inducer of apoptosis in tumor cells, but not normal cells. IL-24 also has antiangiogenic properties. It directly binds IL-24 receptors on endothelial cells, activating STAT3 and blocking their differentiation. IL-24 binds and signals through two heterodimeric receptor complexes. One complex is the combination of IL-20Ra and IL-20Rb, which is shared with IL-19 and IL-20. The second complex is a combination of IL-22R and IL-20Rb, which is shared with IL-20.
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Product Notes
The Human IL-24/MDA-7 (Catalog #AAA309885) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA309885 ELISA Kit recognizes Human IL-24/MDA-7. It is sometimes possible for the material contained within the vial of "IL-24/MDA-7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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