Application Data
Prorenin, Native Protein | REN protein
Human Prorenin, Native
Gene Names
REN; HNFJ2
Purity
>95% by SDS-PAGE analysis
Synonyms
Prorenin, Native; N/A; Human Prorenin, Native; REN protein
Host
Human Embryonic Kidney cells
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid. 0.05M Tris-HCl; 0.15M NaCl; pH 8.0
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
406
UV Absorbance (280 nm)
1.1
Extinction Coefficient
1.1
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -70°C.
Ships on Dry Ice.
Ships on Dry Ice.
Application Data
Application Data
Related Product Information for REN protein
Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2).
Product Categories/Family for REN protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,725 by SDS-PAGE
NCBI Official Full Name
renin preproprotein
NCBI Official Synonym Full Names
renin
NCBI Official Symbol
REN
NCBI Official Synonym Symbols
HNFJ2
NCBI Protein Information
renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme
UniProt Protein Name
Renin
UniProt Gene Name
REN
UniProt Entry Name
RENI_HUMAN
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Product Notes
The REN ren (Catalog #AAA37790) is a Protein produced from Human Embryonic Kidney cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Prorenin, Native, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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