Application Data
Prorenin, C-terminal 8x His tag Protein | REN1 protein
Mouse Prorenin, C-terminal 8x His tag
Gene Names
Ren1; Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352
Purity
>95% by SDS-PAGE analysis
Synonyms
Prorenin, C-terminal 8x His tag; N/A; Mouse Prorenin, C-terminal 8x His tag; REN1 protein
Host
Human Embryonic Kidney cells
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
0.9 mg/ml (varies by lot)
Sequence Length
402
Aliquot
1 x 0.1mg
Volume
0.111ml
Buffer
50 mM Tris; pH 8.0
Extinction Coefficient
1.1
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Application Data
Application Data
Related Product Information for REN1 protein
Recombinantly produced in HEK cell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at C terminus for purification. Resistant to activation to renin by trypsin digestion. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin ezhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N- terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects (2).
Product Categories/Family for REN1 protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,000
NCBI Official Full Name
renin-1
NCBI Official Synonym Full Names
renin 1 structural
NCBI Official Symbol
Ren1
NCBI Official Synonym Symbols
Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352
NCBI Protein Information
renin-1; renin b; kidney renin; aspartyl-protease; angiotensinogenase
UniProt Protein Name
Renin-1
UniProt Gene Name
Ren1
UniProt Synonym Gene Names
Ren; Ren-1
UniProt Entry Name
RENI1_MOUSE
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Product Notes
The REN1 ren1 (Catalog #AAA37805) is a Protein produced from Human Embryonic Kidney cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Prorenin, C-terminal 8x His tag, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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