Neuregulin 1 beta Active Protein | NRG1 active protein

Human Neuregulin 1 beta Recombinant

Cat. Num. AAA14425

• Purity: >95%, as determined by SDS-PAGE
• Synonyms: Neuregulin 1 beta; Human Neuregulin 1 beta Recombinant; neuregulin; nrg1; nrg-1; heregulin; hrg; NRG1 active protein

• Host: Human
• Purity/Purification: >95%, as determined by SDS-PAGE
• Form/Format: Recombinant Human NRG1 is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
• Sequence Length: 607

• Host Note: (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
• Source: Optimized DNA sequence encoding Human NRG1 mature chain >sp|Q02297|2-246 was expressed in CHO cells
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: Store at Room Temperature for 3 weeks or lyophilized at -20 degree C for 12 months.; After reconsitution , Store at at 2-8 degree C for 3 weeks or at -20 degree C for 12 months.; (*)For long term storage we recommend the addition of a carrier protein at 0.1%. (*)Avoid repeated freeze/thaw cycles.

Activity

(The ED(50) was determined by the dose-dependent proliferation of human MCF-7 cells was found to be )

Product Categories/Family for NRG1 active protein

Cytokines

References

• the tyrosine phosphatase shp2 (ptpn11) directs Neuregulin-1/erbb signaling throughout schwann cell development .PNAS, Sep 2009; 10.1073/pnas.0904336106.
• Neuregulin-1β is associated with disease severity and adverse outcomes in chronic heart failure .Circulation, Jul 2009; 120: 310 - 317.
• the relationship among neuregulin 1–stimulated phosphorylation of akt, psychosis proneness, and habituation of arousal in nonclinical individuals .Schizophr Bull, Jun 2009; 10.1093/schbul/sbp063.
• sensory axon-derived Neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance .J. Neurosci., Jun 2009; 29: 7667 - 7678.
• downregulation of neuregulin 1 in retinal ganglion cells in experimental glaucoma .Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 2075.